It is urgent to develop and popularize the early diagnosis technology of metabolic syndrome
We propose the idea of using serum miRNA for early diagnosis of disease
Grade I
Metabolic syndrome (Mets),variously known also as syndrome X,insulin resistance,etc..
is defined by WHO as a pathologic condition characterized by abdominal obesity,insulin resistance.hypertension,and hyperlipidemia.
With the successful conquest of communicable infectious diseases in most of the world,
this new non-communicable disease (NCD)has become the major health hazard of modern world.
Early diagnosis and early intervention in MetS are important to improve the prevention of cardiovascular disease
and type 2 diabetes in adulthood.However.due to the lack of a consensus threshold for screening tools,
and the threshold often marks the irreversible stage of disease progression,patients often miss the best opportunity for intervention and eventually
develop lifelong medication,which costs nearly $4,000 per patient per year,causing a huge personal and socio-economic burden.
It is urgent to develop and popularize the early diagnosis technology of metabolic syndrome
We propose the idea of using serum miRNA for early diagnosis of disease
The concentration of miRNA in the serum is quantitatively converted into different colors by the kit.
and finally the disease is defined by "chromatic aberration"and software algorithms.
The "DIRENJIE"system uses DNA-RNA chimeric ring probe and DNA-cutting activity of DSN enzyme to achieve linear amplification,
and uses the trans-cutting activity of Cas1 2a to achieve exponential amplification,
and uses colloidal gold particles to convert the content of specific microRNA in serum into visible light signals,
achieving the purpose of rapid detection of trace RNA at home.
We shot the bubble results with a mobile phone and analyzed them through the APP to get an easy-to-understand detection report.
In the future,we also want to rely on the APP to achieve telemedicine,guide sub-healthy people to healthy diet and rational drug use.
