We are very eager to establish collaborative relationships with other teams and continue our research on BMCP based on their suggestions. On July 9th, we participated in the China iGEMer Community Conference (CCiC) in the Chinese region. During the conference, we witnessed projects with diverse themes from different regions and felt the warmth and vitality of the synthetic biology community. The three-day conference agenda included academic lectures, team report presentations, poster presentations, special lectures, team discussions, and more. During the conference, we exchanged project designs and progress with other teams, had fruitful discussions, and received collaboration requests from many schools. This made us feel that even though we are in different places, we are all one, and we are all together.
During the conference, we discussed how to use our time effectively to improve the theoretical foundation of our experiments while at home. We also provided innovative points for our project for other teams to reference. After the conference, we decided to collaborate with these iGEM teams. We found that the projects of XJTLU-CHINA and SCU-China were closely related to ours, so the three teams further exchanged project overviews, experimental modeling, social surveys, and more. In addition, we researched appropriate research methods to improve the details of our experiments and increase efficiency.
During the summer vacation, we had academic exchanges with iGEM teams from several schools, including ZJUT-China, XJTLU-CHINA, SCU-China, BIT-China, and others. In our communication, we provided suggestions to other teams and received significant help from them in experiments, HP, and many other aspects. Their guidance provided us with valuable experimental directions and extended our thinking. Furthermore, other teams' methods and ideas about experiments and human practices provided us with excellent ways to try things. We firmly believe that a good experimental experience requires a continuous cycle of communication, suggestions, and improvements. We are also honored to be able to help other teams optimize their projects.
They showcased their modeling approach during the exchange, inspiring us for our modeling direction. We were impressed by their team's mature modeling structure and sought their valuable experience.
We established a long-term and close collaborative relationship with SCU-China, and they provided very practical suggestions for our project (such as suggesting that we consider the impact factors of covalent binding between spytag and spycatcher in experiments). They also paid attention to the details of NEU-CHINA's previous projects and received detailed answers from us. In the future, we will continue to maintain close contact, seek common ground while reserving differences, and progress together.
We participated in an academic exchange meeting attended by multiple schools at the invitation of ZJUT-China. We are grateful to ZJUT-China for providing us with this valuable opportunity, allowing our project to collide with more teams' thoughts, thus gaining improvement and perfection.
XJTLU-CHINA provided guidance for the optimization of our biomembrane growth model, and we also showed them an excellent modeling reference created by our team in previous years, providing some ideas for modeling optimization. The process of exchange and learning was highly efficient. We actively sought contacts and cooperation not only in experiments but also in HP, hoping that our projects could be more comprehensive and demonstrate the charm of synthetic biology to the public."
Universities | Their help to us | Our help for them |
---|---|---|
BIT-China | The BIT-China team presented an introduction to their project, highlighting their modeling approach, which has provided inspiration for our team's future considerations regarding modeling direction. | We provided a venue for academic exchange with the BIT-China team and also explained the content of our project to them. |
SCU-China | The SCU-China team provided a valuable suggestion for our project: to consider the factors affecting the covalent binding of SpyTag and SpyCatcher. Additionally, they suggested exploring more efficient linking methods, such as click chemistry, to replace the SpyTag-SpyCatcher interaction. | The SCU-China team had questions about the 2021 NEU-China team's project, and they reached out to us for assistance. We collected their questions, contacted members of the 2021 NEU-China team to answer them, and provided the necessary clarification. Additionally, the SCU-China team expressed concerns about the suitability of the arabinose suicide switch in the marine environment. They asked whether the arabinose suicide switch could function effectively in the ocean. We provided a detailed explanation of the mechanism of this suicide switch and clarified that it is primarily used during the experimental phase. In practical applications, the biofilm would exist in the form of a mineralized coating. |
ZJUT-China | ZJUT-China invited our team to participate in the Bioremediation-themed academic forum. This opportunity allowed us to engage in more in-depth discussions with like-minded teams and establish future communication. | During the Bioremediation-themed academic forum, our team addressed a question from XJTLU-CHINA regarding the mechanism of enhancing biofilm adhesion. We explained how we achieve the connection between CsgA protein and Mfp protein using spytag-spycatcher, which imparts adhesiveness to the biofilm. |
XJTLU-CHINA | The XJTLU-CHINA team mainly discussed the modeling aspect with us, showcasing their existing modeling work and providing guidance on optimizing our team's biofilm formation model. | Our team presented an excellent modeling reference from previous iGEM teams, which was prepared by one of our team members responsible for modeling, to the XJTLU-CHINA team. This provided them with some ideas for optimizing their modeling. Lastly, our team member responsible for modeling provided a detailed presentation on the secretion model of the Escherichia coli Csg family proteins by the 2017 Harvard iGEM team, suggesting that the XJTLU-CHINA team could refer to this model for inspiration. |