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Title：Starfire：Embedded Exploration of Viral Nucleic Acids and Proteins
Abstract：We design methods for viral RNA research explorations which applied to the HIV-1 isolate ARV-2/SF2 viral genome design for RNA replication for nucleic acid integrase inhibitors, RNA vaccine development, and their potential methods for targeted drug development. Our goal was to utilize the env non-coding long chain RRE RNA and Rev proteins in the viral genome of the HIV-1 isolate ARV-2/SF2 viral strain to develop means that could be used for nucleic acid integrase inhibitors and RNA vaccines as well as targeted drugs. After constructing the RRE and Rev sequences separately, we will mainly carry out systematic studies through in vitro transcription of RRE RNA and its possible interaction with Rev protein. We will accomplish high quality in vitro transcription of RRE by T7 RNA polymerase, search for sites of interest for the interaction of high quality RRE RNA obtained by T7 RNA polymerase transcription with the viral protein Rev.