Nowadays, cancer is one ofthe most pressing healthchallenges, among which Pancreatic Cancer has earned the title of"the king of cancer"due to its alarmingly lowfive-year survival rate.
Pancreatic Cancer
accounts for
3% estimated new cases but 8% estimated new deaths
in all cancers
5-year Survival Rate Estimation
0%
among all cancers
Ranking 6th in China, 4th in the US
Current Treatment
Unfortunately, conventional treatment methods have shown limited efficacy in combatting pancreatic cancer due to the complex anatomical surroundings of the pancreas and immune escape.
Radiotherapy
Many hollow organs are located around the pancreas, which makes it not suitable for the development of radiotherapy
Chemotherapy
There are few specific drug targets, and even if ideal targets exist, they are also easy to mutate
Surgery
The organs around the pancreas are complex, difficult to operate, and easy to relapse
Immunotherapy
There is no conservative and highly-specific immune target
People are calling for new therapies to replace or assist the current treatments. Within 10 years, new technologies such as genetic therapy, CAR-T and RNA therapy have been rapidly developed. Meanwhile, bacterial therapy has also been introduced as a potential alternative.
Our Project
Targeting
Tumour Micro-environment
Stable in tumour tissues compared to antigen
Function
ARG capsules
Detectable by medical ultrasonic, can cooperate with ultrasonic treatment and causing less harm
Concerns and Solutions
Effectiveness
of
Targeting
Effectiveness of Targeting
✔ We designed a hybrid promoter functioning as an AND-gate
✔ Concerning both high lactate and hypoxicity
✔ Lower load compared to traditional AND-gate
✔ We designed a hybrid promoter functioning as an AND-gate
✔ Concerning both high lactate and hypoxicity
✔ Lower load compared to traditional AND-gate
Intravenous
Safety
Intravenous safety
✔ We introduced controllable enveloping concept and designed an MCM model to imitate.
✔ Wet lab solution
✔ Dry lab imitation
✔ A safe strain
✔ We introduced controllable enveloping concept and designed an MCM model to imitate.
✔ Wet lab solution
✔ Dry lab imitation
✔ A safe strain
Social
Concerns
Social Concerns
✔ We launched abundant human practices and educations.
✔ Professional opinions
✔ Patients' experiences
✔ Middle school and College education
✔ We launched abundant human practices and educations.
✔ Professional opinions
✔ Patients' experiences
✔ Middle school and College education
discover more
in our wiki