Overview
Inspiration and Background Research
Currently, LTF is used in a variety of dietary foods, supplements and treatment products. However, the main method of production used industrially today is extraction from secretory fluids of Bovine animals. The optimal LTF for the consumption of human neonates would be human LTF, but human LTF is rather difficult to obtain other than extraction from human breast milk, and mass production using human breast milk raises a series of moral issues. Recombinant production of human LTF is beneficial to people needing the supplement after the end of the breastfeeding period or the children of lactation disfunction patients.
LTF
Lactotransferrin (LTF or Lactoferrin, LF), is aglobular glycoprotein of the transferrin family with a molecular weight ofaround 80kDa(Sources state 76-80kDa depending on glycosylation). LTF iscommonly found in human (mammalian) secretory fluids, such as milk, tears,saliva and nasal secretions. LTF is found most concentrated in colostrum. Incolostrum, LTF acts alongside Immunoglobulins, lymphocytes, lysosomes, lactoperoxidases and other bioactive substances to help the neonate adapt to the non-sterile surroundings andestablish a healthy gastrointestinal biome. LTF, as a kind of transferrinprotein, serves an important purpose in iron regulation and transportation. Isolated hololactoferrin has been used to treat iron deficiencies and anemia.
Lactoferrin has an important role in fueling immune health in infants and children. Lactoferrin is a natural protein with multiple physiological activities, which is involved in a variety of pathophysiological processes such as regulating immune function, anti-microbial, regulating iron absorption, and promoting intestinal cell proliferation and differentiation. In recent years, lactoferrin has been widely used in infants and young children, pregnant women and the elderly, which can reduce the risk of infection in preterm infants, the incidence of respiratory and gastrointestinal diseases in infants and young children, improve anemia in infants and young children and pregnant women, increase the rate of eradication of Helicobacter pylori in children and adults, and improve immune function in the elderly.
References
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