Data from Global Cancer Statistics 2020 shows that the combination of colon and rectum cancer holds for approximately 10% (1,880,725) and 9% (915,880) of all cancer incidence and death in the world respectively .
In Indonesia, colorectal cancer stands at rank 4th and 5th of the most incidence and deaths respectively in Indonesia. It holds approximately 8.4% (33,427) and 7.6% (17,786) of all cancer incidence and death in Indonesia respectively .
A majority of CRC patients are diagnosed at advanced stages due to the difficulties in diagnosis even though early diagnosis plays a crucial role in determining the success of therapy .
However, current early screening methods have their own problems, especially at premalignant stages of CRC and its accessibility in rural areas .
 Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians. 2021 May;71(3):209-49.
 Globocan 2020. Indonesia. World Health Organization; 2021 [cited 2023 September 27]. Available from: https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
 Jogja Cancer Registry. RKBR Maret 2022 – canreg.fk.ugm.ac.id [Internet]. Jogja Cancer Registry. 2022 [cited 2023 May 5]. Available from: https://canreg.fk.ugm.ac.id/laporan-data/registrasi-kanker-berbasis-rumah-sakit-dr-sardjito-fkkmk-ugm/rkbr-maret-2022/.
 Burch JA, Soares-Weiser K, St John DJ, Duffy S, Smith S, Kleijnen J, Westwood M. Diagnostic accuracy of faecal occult blood tests used in screening for colorectal cancer: a systematic review. Journal of medical screening. 2007 Sep 1;14(3):132-7.