In the year 2050, urban skies are abuzz with neon lights and drones. High-speed trains speed between buildings, and people enrich their daily lives with cyber technology.

But Even in this advanced world, a major threat lurks. It is not an exaggeration to say that the threat of super antibiotic-resistant bacteria is real and imminent. The risk of contracting a bacterial infection during surgery or childbirth is much higher than before. The danger of antibiotic resistance has been a concern for a while now. A famous report, known as the O’Neill Report, has stated that by the year 2050, more people will die from antibiotic resistance than from cancer.[1]

The US Centers for Disease Control and Prevention (CDC) reported that by 2019, there have been three million antibiotic-resistant infections in the US, resulting in five million deaths worldwide.[2] It also stated that the number of patients with antibiotic-resistant infections has continued to rise. In Japan, the Government of Japan published a document entitled "Action plan for countermeasures against antimicrobial resistance". It emphasizes the need for clear targets regarding antibiotics and proposes future research in Japan on antibiotic-resistant bacteria.

Even though the mechanism of resistance is understood, it can be said that it is difficult to control with antibiotics as bacteria mutate the genes they hold, reducing the efficacy against antibiotics.Our project develops a CRISPR-Cas9 'master key' solution capable of addressing the mutating antibiotic-resistant genes, offering a potent tool in combating antibiotic resistance