Nomination

Best Therapeutics
Gold medal

Pasta

Phage

Assisted

Silencing

Tool

Against AMR

Press F key & click the DNA

Antibiotic resistance is one of the biggest healthcare threats in the world.

So, we created

P.A.S.T.A.

Phage Assisted Silencing Tool Against AMR

PASTA
Phage Assisted Silencing Tool Agasinst AMR
Hospital
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Number of clinical isolates from bacterial infections in humans per year

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Deaths associated with AMR bacterial infections per year

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Estimated year for AMR to become the main health problem worldwide

Antibiotics
Antibiotics have been misused;
as a result, the remaining
effective ones are now limited.
Therefore, what can be done?
Phage

vs

Bacteria

A new way of conceiving phage therapy combined with CRISPRi technology.

PASTA is about exploiting the potential of phage delivery to cure AMR infections while limiting the selective pressure, thus the rise of new resistance.

Modularity

Modularity

Bacteria can evolve very rapidly, our system has been engineered to quickly adapt

Safety

Safety

Our system has precise tropism, which allows to minimize potential damage to the patient's microbiota and tissues.

Therapy

Phage therapy is currently used for compassionate-care, our system is designed to act as a safe clinical therapy, thanks to its characteristics.

Promotion video

Project description

Design

Results

Human practices