SymbioNex
:Forging a Resilient and Safer TomorrowWhat we wanted to solve
In the realm of synthetic biology, microorganisms, much like diverse teams, adapt and thrive through symbiosis.
Co-culture cultivation in Living Modified Organisms (LMOs) has proven more efficient than monoculture.
Yet, LMO safety remains a paramount concern, underscoring the vital role of bio-safety measures.
Our project aims to create tailored biocontainment systems for co-culture conditions, unlocking the full potential of this innovative approach.
CO-CULTURE
BRING MORE ADVANTAGE in metabolic engineering
BIOCONTAINMENT SYSTEM
IS NOT AN OPTION
LMO FOR CO-CULTURE ENGINEERING ..? ALWAYS BRING DIVERSE ISSUESEven companies related to white-bio struggle with strict
laws and regulations to bring..........
Based on our survey......
2/3 people think LMOs are necessary
But most of the students had concerns about using them,
primarily regarding safety and ecological impact
BIO-SAFETY
ISSUE
SO...WHAT WILL HAPPEN?
CURRENT
BIOCONTAINMENT SYSTEM
HERE IS OUR THOUGHTS
QUORUM SENSING"
we choosed AHL signal molecule and combind it with a toxin-antitoxin system as a suitable kill switch for biocontainment. The system's functionality depends on the concentration of AHL, where a low concentration increases the toxin levels and reduces the antitoxin levels.
- 1) Reduce difficulty of selective containment
- 2) Minimize maintenance costs
- 3) Utilized in diverse organisms
- 4) versatile applications across industries
