Since the outbreak in 2019,
COVID-19 has caused a large number of deaths worldwide,
regardless of each country's economic situation.
Being highly contagious in human society,
COVID-19 has served as a stark reminder of the paramount
importance of precise and rapid disease detection.
PRECISE RAPID
Without a reliable disease detection approach,
It's unimaginable how a similar epidemics will
have an impact on society next time.
AGO
AGO Proteins:
The Key to Timely Disease Intervention
CRISPR systems struggle in
precise and rapid detection as they are bulky,
not sensitive enough,
and rely on specific PAM sequences.
In contrast,
Agronaute (AGO) Proteins
efficiently recognize and cleave both DNA and RNA,
making them ideal for nucleic acid sensing
platforms and virus detection.
Nucleic Acid Sensing Platforms
Virus Detection
However
most AGO proteins
suffer from thermal instability
leading to unreliable results
limited biotechnological applications
Starting from now, don't worry!
Darwins has arrived!
Darwins
Directed Ago Renewal With Ideal proteiN thermal-Stability
A user-friendly software
revolutionizing AGO Proteins
DARWINS can predict protein
thermal stability accurately with
just the protein sequence as input,
reducing prediction time,
to facilitate development of AGO with
high thermal stability, thus promoting
a new virus detection system.
A Brighter Future
DARWINS: A Promising Step
Moreover, our software is designed for diverse proteins,
as our method being promoted widely with the help of our software,
researchers worldwide are empowered to assess
the thermal stability of any protein.
FAST
ACCURATE
USER-FRIENDLY
