Carbon Fast
Synthetic non-oxidative glycolytic pathway for complete carbon conversion
Global warming, rising sea levels, and continued environmental degradation are all linked to carbon emissions. In China, microbial carbon emissions account for 7% of the total, and most of the carbon emissions generated by microorganisms come from sugar degradation. Carbon sequestration is conducive to reducing carbon emissions. This project attempts to introduce a highly active phosphoketolase (F/Xpk) gene into the heterotrophic C. tyrobutyricum, to construct an artificial NOG pathway with high metabolic flux. Compared with the native EMP pathway, this alternative pathway metabolizes glucose into acetyl CoA without carbon loss. We further tried to improve the F/Xpk expression by promoter engineering and ASR. Besides, we found that this engineered strain has a higher ability to utilize cheaper carbon sources. The approach used in this project can be further adapted to a variety of strains with similar metabolic carbon emission issues, thereby contributing to the reduction of global carbon emissions.
"It is necessary to study the fundamental relationships in the natural, social, ecological, economic, and utilization processes of natural resources in order to ensure global sustainable development."
As the most populous developing country, China's carbon emissions cannot be ignored. Currently, the main measures to reduce emissions include the development of renewable energy, energy conservation and energy recycling.
Emissions of greenhouse gases above reasonable levels on a global scale can lead to a cascade of catastrophic and permanent climate change. Global warming, rising sea levels and continued environmental degradation are all linked to carbon emissions.
Sustainable Development Goals (SDGs) are proposed in response to worldwide social, economic, and environmental challenges, the aim of which is to create a more sustainable and equitable future for all.