People need cat!
![](https://static.igem.wiki/teams/4645/wiki/home-picture/need-cat1.png)
With the increasingly affluent living conditions nowadays,
many people want a Cat as their companion.
However, Allergy to cat hair stop people adopting cat.
The allergy affect a lot
![](https://static.igem.wiki/teams/4645/wiki/home-picture/allergy-people.png)
Feline allergies are a common source of allergens, affecting up to 15% of adults and children and causing symptoms such as severe asthma.
Data from the U.S. National Health and Nutrition Examination Survey indicates that Over 5 million asthma attacks occur each year,
![](https://static.igem.wiki/teams/4645/wiki/home-picture/5million.png)
with~350,000 emergency room visits attributed to patients sensitized and exposed to feline allergens.
Fel d 1 causes to allergy
![](https://static.igem.wiki/teams/4645/wiki/home-picture/flow-chart-1.png)
Sensitization to the major feline allergen, Fel d 1 (Felis domesticus allergen 1), elicits IgE responses in >90% of cat-allergic individuals.
Feline allergens are produced by the sebaceous, salivary, and lacrimal glands of cats, and the highest Fel d 1 levels are found in saliva.
![](https://static.igem.wiki/teams/4645/wiki/home-picture/flow-chart-2.png)
![](https://static.igem.wiki/teams/4645/wiki/home-picture/flow-chart-3.png)
When cats groom themselves, Fel d 1 is transferred from saliva to their hair, and cat dander containing Fel d 1 allergen is then spread to the environment as small airborne particles.
There is an urgent need for a new scheme
Despite the prevalence and potential severity of feline allergic disease, current treatments meet a high unmet need.
![](https://static.igem.wiki/teams/4645/wiki/home-picture/allergy.png)
Merely address the allergic symptoms (e.g., Antihistamines).
High cost and inconsistent results (e.g., Feline allergen immunotherapy).
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Short active time and frequent needed (e.g.,Anti-allergy cat food).