Education

Learn, Spark, Dive Deeper

From Lab To Public

In today's modern world, where scientific advancements are progressing at an unprecedented rate and the threat of misinformation looms large, it is imperative to provide the general public with sound and precise knowledge. The intricacy of science can often appear daunting, and this is precisely where we step in. Our primary objective is to translate complex scientific theories, concepts, and discoveries into a language that is comprehensible to all, regardless of their educational background.

We firmly believe that education and effective communication are paramount in a world dominated by technology and science. A well-informed public is better equipped to make informed decisions, think critically, and actively participate in discussions that shape and advance our society.

Our outreach programs for this year have been meticulously designed with a multifaceted approach. We aim not only to disseminate knowledge but also to ignite interest in science and foster curiosity. Through workshops, seminars, interactive events, and online publications, we aspire to reach diverse age groups and educational backgrounds.

Some of our strategic goals include:

  1. Promoting scientific thinking:
    We want individuals to learn to critically question information and argue based on facts.
  1. Engaging the community:
    Through community projects and events, we aim to actively involve people in the scientific discourse.
  1. Collaborating with educational institutions:
    We plan to forge partnerships with schools and universities to provide educational materials and resources.

Our target audience is diverse, ranging from students to adults and seniors. We believe that everyone has a right to education and can benefit from our program.

In conclusion, we wish to emphasize that the measurable outcomes of our public engagement initiatives can be seen not just in numbers but also in the quality of discussions, understanding, and interest in science. It is our mission to bridge the gap between science and the public and heighten awareness of the significance of education in our society.

But...What Does The Public Say?

Effective science communication reaches its full potential when it addresses the audience's individual knowledge demands. As a result, it was critical for us this year to base our educational initiatives on solid data and honest feedback. We started a survey to get an initial viewpoint and a clear picture of the public's level of awareness.

Framework

The following aspects characterize the framework and intention of this study:

  • Objective:
    Our primary concern was to capture the understanding and perception of the general public regarding antibiotic resistance. This would assist us in tailoring our educational strategies and developing targeted awareness campaigns.
  • Participant Selection (fig.1a + 1b):
    In our study, we surveyed 239 individuals representing diversity in terms of gender, cultural background, and educational level. The age spectrum of the participants ranged from under 16 to over 60 years, ensuring a multifaceted representation of opinions. We disseminated the survey widely across various platforms, social media channels, community groups, and educational institutions.
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Fig 1a.: Overview of the age distribution of survey participants.

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Fig 1b.: Overview of the gender data of the survey participants.

  • Methodology:
    To create an objective and comprehensive data foundation, we designed a digital questionnaire. This combined multiple-choice questions, open-ended responses, and interactive ranking tasks, actively involving the participants.

All of our statistical surveys were completed anonymously, in accordance with the GDPR requirements, and after obtaining the required "distribution license" from our university's Department of Processing Personal Data.

Time To Reflect

Our survey aimed to gauge the level of understanding and awareness among respondents regarding antibiotics and their scope. A commendable 95% of participants correctly identified that antibiotics primarily target bacteria. However, 18% of participants mistakenly believe that they can also be used against viruses and fungi, which is a common misconception among the general public. (fig.2). 15% of participants also state that antibiotics can also be used against parasites, an assumption that is confirmed in rare cases shown in this publication.

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Fig 2.: Overview of survey responses to the question: Against which pathogens can antibiotics be used?

While 42% of respondents say about themselves, they could accurately define "antibiotic resistance" (fig. 3), it's worth noting that this might be influenced by their professional backgrounds and exposure to scientific research (fig. 4). Unfortunately, 15% of respondents had minimal to no understanding of the topic at all (fig. 3).

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Fig 3.: Overview of survey responses to the question: How well do you know the term antibiotic resistance? (1 means "never heard of it" and 5 means "I could explain the term to others")

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Fig 4.: Overview of survey responses to the question: Which sources do you use to learn more about antibiotic resistance?

Before participating in the survey, 20% were unaware of the link between excessive antibiotic use and the development of resistance. This lack of awareness is particularly concerning, especially when coupled with the fact that nearly one-third of respondents do not proactively seek information about antibiotics. Moreover, half of the participants haven't contemplated the long-term implications, such as the potential ineffectiveness of antibiotics in the future (fig. 5).

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Fig 5.: Overview of survey responses to the question: How often do you think about the fact that antibiotics may soon lose their effectiveness? (1 being never, 5 being regularly)
A Shared Responsibility

Combating antibiotic resistance is undeniably one of the most urgent challenges of our time. The question of who should shoulder the responsibility for public communication and proactive measures is crucial. The subsequent data (fig. 6) provides a window into public expectations and perceptions about this responsibility.

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Fig 6.: Overview of survey responses to the question: Please rank the following actors from most to least responsible to take action to combat antibiotic resistances

The overarching sentiment is that international and national governments should be at the forefront of this battle. This aligns with the traditional view that governments are the primary responders to global health crises. The message to policymakers is clear and resounding: Mere allocation of resources won't suffice. A well-coordinated, strategic approach is imperative to tackle the mounting challenges posed by antibiotic resistance.

The positioning of patients in seventh place is particularly revealing. It indicates that, although individuals play a role in antibiotic usage, the public believes the bulk of responsibility lies with larger organizations and institutions. This could also reflect the belief that patients often rely on the advice of experts and not see themselves as primarily responsible for the general development of resistance. However, this conflicts with the fact that the government does provide educational material that can be understood by laypersons.

The placement of the pharmaceutical industry in third place, even before medical professionals and scientists, is also noteworthy. This could mirror the general sentiment that companies benefiting from the production and sale of antibiotics should take a proactive role in educating and training both professionals and consumers about their use.

The high ranking of scientists in this list is both encouraging and challenging for us as a research community. It demonstrates that the public recognizes the value and importance of scientific research in this domain. It also reminds us that we play a central role in seeking sustainable solutions to this pressing issue. It's our duty to develop innovative approaches and share our knowledge with other stakeholders to collaboratively counter the threat of antibiotic resistance.

Exploring New Frontiers

The survey reveals that 63% of respondents are skeptical of antibiotic prescriptions and do not believe they are prescribed only when truly necessary (fig. 7). This distrust could be attributed to a myriad of factors, including widespread reporting on the overuse of antibiotics and the resulting resistances. Only a quarter of participants expressed no concerns regarding prescription practices (fig. 7).

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Fig 7.: Overview of survey responses to the question: Do you have the impression that antibiotics are only prescribed when they are truly necessary?

This fact overlaps with the overwhelming 86% willingness to explore new therapeutic approaches for treating bacterial infections. This suggests an openness to innovations and alternative treatment methods. However, when asked about their familiarity with such strategies, 70% of respondents admitted to not knowing any alternative approaches to antibiotics for combating bacterial infections. This underscores the need to raise awareness about other therapeutic possibilities.

Additionally, a substantial number of respondents demonstrated a lack of familiarity with pivotal organizations and strategies dedicated to addressing this issue. A staggering 90% admitted to having no knowledge of the "European Committee on Antimicrobial Susceptibility Testing (EUCAST)," an international body that plays a crucial role in setting standards and guidelines related to antimicrobial resistance.

Furthermore, when narrowing the focus to Germany, the data reveals that 83% of the respondents were unaware of the national "DART" strategy. The "DART" strategy, which stands for "Deutscher Aktionsplan zur Resistenzbekämpfung (German Action Plan on Resistance Control)" is a comprehensive plan initiated by the German government to combat the rising threat of antibiotic resistance. This strategy encompasses various measures, including promoting research, enhancing surveillance, and educating healthcare professionals and the public about the prudent use of antibiotics.

These findings underscore the importance of bolstering public awareness campaigns and educational initiatives. It is essential for the public to be informed about antibiotic resistance and the organizations and strategies in place to combat it, as collective understanding and action are vital in addressing this global health concern.

Take Home Message

The survey results indicate a significant need for more education on antibiotic resistance, including its origins and prevention. The uncontrolled spread of antibiotic resistance poses a threat to current healthcare systems and future generations' health.

The Collective Responsibility:

It's clear that tackling antibiotic resistance can't be done by one institution alone. It requires a collaborative effort from a diverse range of actors, including governments, healthcare professionals, the pharmaceutical sector, researchers, and the general public. Each group must contribute their expertise and resources to combat this issue.

The Role of Science Communication:

Furthermore, the survey results emphasize the importance of effective science communication. In an era where misinformation can spread rapidly, clear, accurate, and accessible communication about scientific matters is paramount. Especially in areas as crucial as antibiotic resistance, where misconceptions can have dire consequences, the role of science communicators becomes even more vital.

Our Response and Future Initiatives:

Based on the data we have collected, we are well-positioned to create educational initiatives that are effective and useful. Our aim is to do more than just share information - we want to encourage a deeper understanding, promote critical thinking, and empower people to make informed decisions regarding the use of antibiotics.

In order to expand our reach and make a lasting impact, we are considering partnering with educational institutions, healthcare organizations, and community leaders. By utilizing their networks and influence, we can ensure that our educational programs reach a wider audience and have a greater impact. Our approach includes various methods such as workshops, webinars, community engagement events, and digital campaigns.


To sum up, although the issue of antibiotic resistance may seem daunting, there is a clear determination to confront it. Through specific educational programs, cooperation, and transparent communication of scientific information, we can encourage a well-informed and proactive community that is prepared to confront the challenges of antibiotic resistance directly.


The Art Of Storytelling

It's no longer sufficient to merely present research findings; it's imperative to convey these insights in a manner that's both accessible and engaging to both peers in the field and the general public. This shift emphasizes the importance of clarity, relatability, and the art of storytelling in scientific narratives. Recognizing the nuances and challenges of this endeavor, we turned to a distinguished expert in scientific communication to enhance and refine our approach, ensuring that our messages are both informative and compelling.

Goal

Our main goal is to equip ourselves with the essential tools and methods that allow for seamless delivery of complicated scientific content and ensure that it is both educational and engaging. We place paramount importance on catering to diverse learning styles, recognizing that each individual absorbs information uniquely. By intertwining auditory, interactive, and visual learning approaches, we aim to create a holistic educational experience.

Our collaboration

In collaboration with Julia Pawloski, the workshop was made possible by the ISA Center of the University of Hamburg ISA Center of the University of Hamburg. As a research assistant in the project Digital And Data Literacy In Teaching Lab (DDLitLab), her focus is on the visual preparation and design of teaching materials, as well as visual (science) cummunication in digital offerings.

3 Essential Takeaways

Target Audience Identification

Determining the target audience is crucial for the way scientific information is presented. The more specific the target group, the more prior knowledge can be assumed. This was illustrated in the workshop by the example of a pyramid ranging from general party guests to professional colleagues.

Visual Imprinting

The significance of colors and visual elements was underscored. Colors can act as attention-grabbers, directing focus to specific data, or be used for visual guidance and hierarchy. It was stressed that color selection should be judicious to avoid conveying misleading information. Audience expectations should be complemented by "viewing habits.”

Key Term Utilization

Key terms can vary in meaning depending on context. It's imperative to define and research these terms in advance to ensure accurate usage. The workshop advised searching for key terms across categories such as "science," "popular," and "children," linking them to the respective research domain.


Equipped with the right tools, we are now well-prepared to independently conduct scientific communication at a high standard.


Interdisciplinarity

There is no denying that in contemporary society, working alone is often unavoidable when striving to achieve an ultimate goal. However, when it comes to teamwork, interdisciplinary collaboration plays a pivotal role in enhancing the quality and quantity of various aspects, including communication, problem-solving, and project management.

Goal

The goal of the workshop centered around the activities and insights of our iGEM team. We aimed to enhance individual interdisciplinary competencies and maximize the potential of teamwork within the iGEM framework, with a particular focus on communication, conflict resolution, scientific communication, and project management.

Our collaboration

We have participated in a workshop on interdisciplinarity, led by Dr. Mirjam Braßler from the ISA Center of the University of Hamburg - an initiative that promotes interdisciplinary study programs and supports the exchange between different scientific disciplines.

Motivation

The underlying motivation for our interdisciplinary teamwork became evident as we discussed the challenges of addressing complex issues that demand expertise from multiple fields. We realized our responsibility towards society and acknowledged that true innovation thrives when we appreciate and understand how individuals from diverse disciplines think.

The workshop explored various forms of collaboration, beginning with disciplinary and multidisciplinary efforts, where disciplines work alongside each other. The heart of our narrative revolved around the world of true interdisciplinary and transdisciplinary collaboration. In these spaces, problems are collectively addressed, disciplines integrate on equal footing, and no single discipline dominates the discussion.

Our iGEM team's position within this spectrum was reflected upon. We highlighted our multidisciplinary work in topic selection and research, our interdisciplinary attempt in laboratory planning, and our transdisciplinary engagement in Human Practices and Public Engagement.

What We Have Learned

A central theme of our workshop was the development of interdisciplinary competence. This involved understanding the perspectives of different disciplines, integrating them, and reflecting on the challenges, achievements, and limitations faced.

Effective communication was another crucial aspect. We emphasized sharing knowledge, using simple language, active listening, and fostering creativity in communication. Clear and concise language was key, and we stressed the importance of maintaining the audience's interest.

The workshop also addressed strategies for dealing with interdisciplinary conflicts, with an emphasis on maintaining respectful communication, understanding, and keeping the shared vision in sight. We encouraged distinguishing between criticism of the discipline and the individual.

Scientific communication emerged as a vital skill, focusing on clarity, audience-tailored communication, and defining communication goals.

The workshop culminated with an exploration of project management, where we tackled the typical challenges that arise. We presented eight tips for more effective project management.

Take Home Message

Our journey as an iGEM team could inspire others to embark on their own interdisciplinary adventures. The key takeaway was that strengthening interdisciplinary competencies, unlocking innovation, and achieving remarkable results are attainable goals for anyone willing to invest in effective communication, conflict resolution, and project management. This message underscored the idea that interdisciplinary teamwork can transform complex challenges into remarkable opportunities.


Shaping Young Minds

Inspired by the insights from our study, we aimed to promote science communication in settings where it can be effectively implemented, irrespective of social or cultural backgrounds. Schools, as educational institutions, present an ideal platform to directly engage the younger generation, thereby laying a robust foundation for their future education and career paths. It's imperative to ignite the scientific curiosity of the upcoming generation and equip them with the skills they need to make informed decisions in an increasingly complex world, critically evaluate information, and discern between well-founded facts and misinformation.

Goal

Our primary objective was to provide students with a comprehensive, interdisciplinary learning experience right within their classroom setting. Central to this endeavor were the concepts of "synthetic cell biology" and “antibiotic resistance”. We aimed to facilitate an interactive engagement with the fundamental principles of molecular biology for the students, bridging the gap between theory and practice. Pedagogically, our goal was to encourage students to formulate their own hypotheses for complex issues and to draw independent conclusions based on their observations.

Our collaboration

iGEM@school was made possible through the collaboration of two eleventh-grade classes from Hamburg's Gymnasium Ohmoor, as well as the sponsorship of Dr. Skadi Kull. As the director of the student lab "Molecules & Schools" at the University of Hamburg's Department of Chemistry, a part of the CUI Excellence Cluster "Advanced Imaging of Matter," she possesses a wealth of expertise in both scientific and scholastic education. With her support, we introduced “biobits”, the "Building Blocks of Life" kit, produced by (miniPCR) and the Hamburg iGEM Team 2020, to classrooms in Hamburg.

How does BioBits® work?

The BioBits-Cellsystem is an excellent example of how synthetic systems can illustrate transcription and translation, and make gene flow visible through fluorescent signals. The BioBits are molecular factories that can produce a broad range of proteins without the need for cell culture. They contain all necessary cellular components, including ribosomes for translation and RNA polymerases for transcription, along with essential building blocks such as ribonucleotides for mRNA synthesis and amino acids for protein synthesis. Additionally, they contain ATP as a source of energy for reactions. The pellets are inactive when dry, but can be made active by adding water. To visualize protein biosynthesis, DNA is used, with each encoding a green and a red fluorescent signal, to display in real-time the production of RNA (green) and protein (red).

Overall, four reactions are carried out during the experiment, allowing for the examination of the central dogma and the opportunity to interrupt particular molecular flow steps.

Building Blocks of Life

The course was thoughtfully structured to provide a mix of theory and practical experience. It began with a detailed safety briefing and an informative introduction to genetics, followed by a comprehensive overview of transcription and translation fundamentals.

Subsequently, students were ushered into their first hands-on activity. Each participant was given an opportunity to familiarize themselves with the intricacies of using an Eppendorf pipette through a dedicated pipetting exercise.

With our expert guidance, students were able to apply their newly acquired skills. They worked in groups and accurately pipetted reagents into designated tubes, following the requirements (fig. 8). The reactions they created were classified as:

  1. BioBits®-Pellet + water
  2. BioBits®-Pellet + water + coding DNA A
  3. BioBits®-Pellet + water + coding DNA A + antibiotic
  4. BioBits®-Pellet + water + DNA B
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Fig 8.: Representation of the BioBits®-Pellet tubes to which water, DNA A, DNA B and spectinomycin are added according to the indicated volumes. Source from Molecules and Schools Kit "Building Blocks of Life".
Results

After incubation periods of t=0, t=15 min, and t=8 h, the outcome should be observed in a fluorescence viewer (fig. 9). In order to uncover explanations and potential sources of error that could account for variations from the anticipated results, the students were invited to discuss the findings in small groups. Table X. illustrates the results of the color reactions:

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Fig 9.: Fluorescence observation after incubation periods of t=0, t=15 min, and t=8 h. Source from Molecules and Schools Kit "Building Blocks of Life".

What explanation fits these observations?

Tube 1 contains only BioBit pellet and water, resulting in no green or red fluorescence.

Tube 2 contains BioBit pellet, water, and coding DNA A the presence of mRNA can be detected after 15 minutes by observing a green fluorescence emitted by the RNA aptamer. Protein translation can be detected by observing red fluorescence after 8 hours due to the protein-coding sequence.

Tube 3 contains BioBit pellet, water, coding DNA A, and spectinomycin. Spectinomycin is an antibiotic that acts as a translation inhibitor and thus prevents the production of proteins.

Tube 4 contains BioBit pellet, water and DNA B. The fluorescence viewer shows the formation of only RNA aptamer without production of red fluorescent protein. What is happening in Tube 4?

  • The protein is rendered inactive by a mutation in the DNA's coding sequence.
  • A start codon or a stop codon is absent.
  • A premature stop codon has been added by a mutation in the DNA.

In conclusion, the session culminated in a comprehensive plenary discussion where the gathered data was meticulously analyzed. Students actively engaged in dialogue, sharing their observations, insights, and interpretations, fostering a collaborative learning environment. This collective reflection not only solidified their understanding but also encouraged critical thinking and peer-to-peer knowledge exchange.

Link to our project

Our educational program is deeply rooted in our project goals. With the introduction to our iGEM project this year, we aimed not only to provide the students with theoretical knowledge, but also to show them its practical application in the real world.

A central element of this educational approach was the process of protein biosynthesis. Through this, we were able to illustrate to the students the fundamental principles of the central dogma of molecular biology and use them to explain our laboratory work with ferritin. Knowledge of protein production is essential to fully grasp the breadth of our project.

With our educational initiative, we aimed to bridge the gap between theoretical knowledge and practical application. By aligning our program with our project goals, we aimed to inspire students to look beyond the confines of their textbooks and imagine the limitless possibilities that await in the world of scientific research and innovation.

Take Home Message

The essence of our program lies not just in imparting knowledge, but in empowering students to discern, evaluate, and chart their own paths in the vast realm of science. Every individual has a unique inclination, be it towards the tangible world of laboratory experiments or the abstract realm of theoretical studies. Our program acknowledges and celebrates these differences, ensuring that each student, regardless of their preference, feels valued and understood.

In the process of curating and delivering this program, our own learning curve was steep. Designing an educational initiative of this magnitude allowed us to step into the shoes of educators, giving us a newfound appreciation for the intricacies of lesson planning and the challenges of classroom management. Engaging directly with students was a transformative experience. It underscored the importance of empathy, patience, and adaptability in teaching. By communicating on equal footing, we were able to foster an environment of mutual respect and trust, which is pivotal for effective learning.

Feedback is a powerful tool, and the insights we gained from our participants were invaluable. They not only highlighted areas of improvement but also reaffirmed the aspects of our program that resonated most with the students. This iterative feedback loop has been instrumental in refining our approach, ensuring that our program remains relevant, engaging, and impactful.


Empowering The Next Generation

Science and technology are the pillars of progress and innovation. Despite their importance, however, there is still a significant gender gap in these fields. As of 2019, a mere 22.6% of employed STEM graduates were women, and this number dwindles further to 10.8% for STEM professionals, as indicated by this source. Such statistics not only highlight women's underrepresentation in STEM but also emphasize the pivotal juncture we are at. It's about time we bolster our efforts to foster and amplify the talents of young women, ensuring a more balanced and inclusive future in science and technology. Recognizing this challenge, we felt compelled to take proactive measures. As part of our dedicated efforts to address this imbalance and foster a love of science and technology from a young age, we are pleased to have been able to offer a comprehensive workshop for this year's Girls’ Day.

Goal

Our mission goes beyond just education; it's about inspiration and empowerment. We want to show young women the tremendous opportunities that STEM fields offer and hope to ignite their passion that might lead them to consider careers in these traditionally male-dominated fields. Through engaging hands-on experiments and interactive discussions, we aim to open a door for them toward science and showcase the diversity of STEM fields. In doing so, we hope to pave the way for a more inclusive future in these important fields.

Our collaboration

Our program was made possible through collaboration with the Schülerforschungszentrum Hamburg, a facility that specializes in providing young people with an area for STEM research and experimentation. Through their support, we were allowed to use their space as well as certain essential lab supplies. With a theoretical and a practical component, our event was presented as two rotational workshops that were thoroughly and visually integrated into the overall topic of our this years project.

Furthermore, we are deeply indebted to MINTfit for their generous sponsorship of promotional materials.

Addressing the Global Challenge: Educating on Antimicrobial Resistance

In our effort to foster a deeper understanding of pressing global challenges, we have developed a theoretical unit that addresses the intricacies of antimicrobial resistance and multidrug-resistant bacteria.

Theoretical Foundations

In the first section, the participants were given a basic understanding of bacteriology. We emphasized the complexity of bacterial behavior, their adaptive mechanisms, and the consequences of improper use of antibiotics. However, the emergence of antibiotic-resistant bacteria is not only a medical challenge but also a societal issue. The overuse and misuse of antibiotics in humans, animals, and agriculture are exacerbating this crisis. Therefore, educating the younger generation about this problem is not only beneficial but also necessary. By instilling knowledge and awareness at a young age, we aim to cultivate a generation that is well-informed and proactive in addressing this global threat.

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Fig. 10: Presentation at the Girl's Day.
Engaging with Innovation

A special highlight of the theoretical part was the presentation of our self-developed game that breaks down the resistance mechanisms of bacteria. Our interactive “antibiotic resistance” game provided a fun learning atmosphere for the students to grasp complex scientific concepts in an accessible and entertaining way. It described the mechanisms by which microorganisms become resistant to antimicrobial agents and stressed the importance of judicious use of antibiotics and the search for novel therapeutic approaches. For a detailed overview and insights into the mechanics and goals of the game, we invite you to explore our Antibiotic Resistance Game documentation.

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STEM education through hands-on experience

For the hands-on portion, our intention was to provide a fun and interactive context for the many STEM fields. Rather than focusing solely on dry theory, we emphasized accessibility and sustainability. The hands-on experiments were designed to teach the fundamentals of several scientific disciplines, including chemistry, nanoscience, biochemistry, and biology, in a relevant and tangible context.

Safety first

Before the students entered the practical part, they received a comprehensive safety briefing for the laboratory. This ensured that they understood the necessary precautions and behaviors in the lab environment. Throughout the practical section, they were constantly monitored to ensure their safety. As advisors, we were always available to answer questions and provide further guidance.

Hands-on experience

Each technique selected served a dual purpose: to enlighten and to ignite passion, seamlessly connecting theory with hands-on experience in a captivating manner. After the experiment, students delved into group dialogues to scrutinize the gathered data. This endeavor sharpened their analytical prowess, prompting them to pinpoint discrepancies and unexpected results. The session culminated in a candid feedback session.

Biology

In order to familiarise the students with the complex world of bacterial microorganisms, we opted for a hands-on approach that allowed them to perform microscopy themselves. We explained the basic principles of light microscopy and emphasised the nuances of illumination and the importance of objective magnification. In addition, we delved into the study of cell morphology and imparted knowledge of the various shapes, arrangements and structural intricacies of harmless bacterial cells. This educational demonstration was crucial as it provided students with an authentic and challenging visualisation of cellular entities, promoting a deeper understanding of the complexity of microbiological studies.

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Biochemistry

In the area of biochemistry, our educational focus was on elucidating fluorescence phenomena. The demonstration emphasized the emission of fluorescence in a manner congruent with the environment by having the students extract chlorophyll from leaves and analyze it under a UV device. Beyond the realm of organic chromophores, the ubiquity and importance of fluorescent proteins, particularly green fluorescent protein (GFP), was highlighted. GFP, derived from the jellyfish Aequorea victoria, serves as a luminescent marker in cellular and molecular biology, enabling real-time visualization of cellular processes. This was a key discussion point highlighting the advances and applications of fluorescence microscopy in contemporary research and the relevance to our study of the spatial localization of cell penetrating peptides.

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Chemistry

Our focus within the field of chemical research was on catalytic reactions, specifically clarifying their function as kinetic enhancers in reaction systems. We carried out the exothermic decomposition experiment known as "Elephant's Toothpaste" using materials found in most homes, including hydrogen peroxide (H2O2), Saccharomyces cerevisiae (commonly referred to as baker's yeast), dihydrogen monoxide (H2O), and surfactant solutions (dishwashing liquid). This experiment clarified the nuances of reaction rate augmentation and served as a concrete example of enzymatic catalysis, making complex chemical phenomena more understandable.

Nanoscience

To ensure a comprehensive insight into the STEM field, we additionally offered nanoscience as an integrative discipline linked to synthetic cell biology. This exploration was enriched by the inclusion of experiments illustrating the unique properties and behaviours at the nanoscale. These included the Tyndall effect, which demonstrates the scattering of light by colloidal particles; the lotus effect, a phenomenon in which water droplets bead off a surface, mimicking self-cleaning properties; and the study of gold nanoparticles, which exhibit special optical properties due to their size- and shape-dependent surface plasmon resonances. These experiments were particularly effective in describing the broader applications of nanotechnology and threading this physicochemical discipline into the context of synthetic cell biology in the future.

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Take Home Message

Our initiative to introduce young girls to the world of science was not just an educational endeavor but also a step towards a more inclusive and diverse scientific community. The underrepresentation of women in STEM fields is a deeply rooted issue that we aim to address through workshops like these. By blending theoretical knowledge with interactive learning methods, our goal was not only to educate the participants but also to ignite their passion for research and inspire them to envision themselves as future leaders in STEM fields. The overwhelmingly positive feedback indicates that we struck a chord, with many young girls now expressing a newfound interest in pursuing a career in science and technology. This reinforces our belief that such initiatives not only spark interest but also play a pivotal role in breaking down gender stereotypes. Upon reflection, it's evident that the amalgamation of education and inspiration is the key to driving sustainable change and paving the way for a more inclusive and diverse future in STEM.


Back To The Roots

Antibiotic resistance is a global challenge that knows no age boundaries, impacting everyone from the youngest child to the eldest adult. Recognizing the gravity of this issue, we felt a pressing need to initiate an educational campaign that would resonate with families as a whole. While our previous events successfully reached out to children, sparking their interest in the vast world of STEM, we realized that to truly make a lasting impact, we needed to engage their primary influencers: their parents. By involving parents, we not only aim to educate them about the critical issue of antibiotic resistance but also to inspire them to motivate and support their children in pursuing careers in the STEM fields. The annual Hamburg Family Day provided the ideal platform for this endeavor, allowing us to connect with families and emphasize the collective responsibility we all share in addressing antibiotic resistance.

Goal

In the context of the Family Day workshop, our primary objective was to cast a wide net, ensuring that every participant, regardless of age or background, found something of interest. To achieve this, we designed a diverse range of activities organized in a station rotation format. This approach allowed participants to move from one engaging activity to the next, ensuring a dynamic and interactive experience. Ultimately, our goal was not just to inform but to inspire. We wanted to ignite a passion for science, emphasizing the wonders of synthetic cell biology and its potential to revolutionize the way we understand and interact with the world around us.

Our collaboration

The successful realization of the Family Day event was made possible through a collaboration with the Schülerforschungszentrum Hamburg. Their tireless support and shared vision for promoting science and technology education provided the perfect foundation for our initiative. Furthermore, we express our gratitude to the organizers of the Family Day for efficiently approving our event, allowing us to dedicate our efforts to delivering a memorable experience for all participants.

Station race

At the core of our workshop was a dual mission: to raise awareness about the competition and to impart knowledge about synthetic cell biology. To ensure that our message resonated with attendees of all ages, we designed a diverse range of activities, each tailored to different age groups and levels of understanding.

1. iGEM Introduction

Upon arrival, attendees were briefly introduced to iGEM and our mission, as well as the competition's history and its foundational concepts.

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2. Triplet Game

For our younger enthusiasts, the innovative Triplet Game was a hit. Through this engaging activity, they were introduced to the intricacies of DNA and the principles of evolution, making complex topics accessible and fun.

3. Antibiotic Resistance Game

A highlight of our workshop was the cross-generational Antibiotic Resistance Game. This interactive game revolved around the ongoing battle between researchers and a multi-resistant bacterium. It offered participants a deeper understanding of antibiotic resistance, emphasizing its significance in today's world.

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4. Crafting Station

To provide a hands-on experience, we established a crafting station where participants had the opportunity to design their own therapeutic delivery system. This activity not only allowed them to visually represent our project but also gave them a tangible memento to take home, reinforcing the workshop's key takeaways.

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Take Home Message

The interaction with a heterogeneous audience has underlined the essential importance of differentiated didactic approaches, adapted to diverse age cohorts and educational levels. It was remarkable to witness the ubiquitous enthusiasm and scientific curiosity across all age groups, affirming the universal relevance and resonance of scientific topics.

In particular, the resonance of parent participants was revealing. A significant proportion expressed that they proactively seek such educational opportunities for their offspring, but are confronted with an evident mismatch between need and available programs. This implies a clear gap in current educational offerings and underscores the imperative need for such science education initiatives.

These findings highlight the central role of academics in the public education landscape. It is incumbent upon us to bridge the gap between scientific research and the general public in order to promote both understanding and interest in scientific disciplines in a sustainable manner.


German Unity Day

On October 3, 1990, Germany witnessed a historic moment as the Federal Republic of Germany (BRD) and the German Democratic Republic (DDR) united to form a single nation. This day, celebrated as the German Unity Day, symbolizes not just the political reunification but also the unity and community spirit of the people in the newly formed country.

Goal

Amidst the great festivities, we had the privilege to represent Hamburg at a large science booth. Our primary goal was to present our project transFERRITIN and iGEM to a wide audience to ensure that everyone, regardless of their background or age, can grasp the essence of our work.

Our collaboration

The German Unity Day has been commemorated with ecumenical service, a state ceremony, a speech by the current President of the Federal Council, and a citizen festival. Each year, a different federal state hosts these festivities, and this year, Hamburg had the honor for the third time. The celebrations spanned across the Alster and Elbe, with a national mile in the city center, speeches by dignitaries, and a vibrant citizen festival expected to attract hundreds of thousands from across the country.

MOIN Zukunft

Our booth was located in the science tent MOIN Zukunft (”Hello Future”) on the "Associations and Institutions Mile". Drawing inspiration from our previous engagements on Girls’ Day (Link) and Hamburg Family Day (Link), we adopted a hands-on approach. We showcased our self-developed antibiotic resistance game (Link), where visitors could combat resistant bacteria, thereby understanding the significance of our modular drug delivery system. To further simplify our project, we crafted modular ferritin containers using origami, visually representing our work and making complex processes more tangible. This hands-on representation piqued the curiosity of many, leading to engaging conversations.

Additionally, we programmed a dedicated website for German Unity Day, available here. Through this website, we aimed to allow visitors to delve into our project transFERRITIN, iGEM, and the topic of antibiotics at their own pace. Therefore, the site contains further information about us and our project, presented in an informal and straightforward manner.

Visit Of The Second Mayor

Our efforts did not go unnoticed. Ms. Katharina Fegebank, the second mayor of Hamburg and senator for the Department of Science, Research, and Equality, graced our booth. She took a keen interest in our project, engaging in a meaningful dialogue and appreciating our endeavors.

Take Home Message

The German Unity Day celebrations provided us with a platform to showcase our passion for science and the importance of our project. The diverse crowd at the festival provided us with a unique opportunity to interact with people from various age groups and backgrounds. From children intrigued by our origami balls to adults keen on understanding the nuances of our project, our booth became a melting pot of inquisitiveness and knowledge sharing.

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Peer-To-Peer-Learning

Conveying scientific insights to budding young researchers is an inspiring endeavor. But who is behind such instructive workshops? That's us! Consequently, we equally see it as our mission to convince already decided STEM students not only for their own scientific projects, but also to win them for international competitions, such as iGEM.

Goal

Our aim was to introduce and promote the iGEM competition and our project, transFERRITIN, to the student community. We aimed to share the essence of iGEM, its objectives, the intricacies of launching a research project, and the invaluable insights and skills one can acquire through participation.

Our Collaboration

The event was made possible as part of a summer campus party hosted by the Junior-German Society for Biochemistry and Molecular Biology e.V. (jGBM) together with the Student Council of Biology and Molecular Life Science of the University of Hamburg.

Welcome To Synthetic Biology

iGEM Memory Game

Through a playful approach, we introduced STEM students to the key concepts of the iGEM competition. Our self-developed memory game provided an interactive and visual way to showcase the diversity of an international competition like this and offer insights into our own project work. By fostering an informal and open discussion environment, we were able to captivate students from various disciplines, elaborating on the inter- and transdisciplinary nature of the competition.

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Triplet Game

Our Triplet Game also resonated well with the students. Through this game, we aim to simplify and playfully illustrate the impact of synthetic cell biology and its basic functioning. The goal of our Triplet Game is to create a being encoded by triplets, which players can individually arrange on a crafted DNA strand. At the summer festival, numerous unique and extraordinary beings were created, too many to showcase them all.

It was fantastic to observe students enthusiastically trying out our games and ambitiously seeking combinations that we couldn't encode. Unfortunately, we had to disappoint all players of our Triplet Game in this regard, as we can encode every single DNA sequence, and each sequence leads to a unique being.

Introduction to our project

To dice deeper into our project, we offered a revised edition of our antibiotic resistance game.


Take Home Message

The summer festival proved to be a resounding success. Not only did we manage to pique the interest of many fellow students, potentially sowing the seeds for the iGEM Team 2024, but we also had a blast with our games. The event provided us with a platform to share our passion for iGEM and synthetic biology, and the experiences we garnered at our booth were truly invaluable.


Spotlighted in BIOspektrum!

The presentation of our project in a scientific journal offers a unique opportunity to make our own research projects accessible to a broad professional audience. It not only allows validation of the work by experts in the field, but also the exchange of ideas and feedback that can contribute to the further development and refinement of the project.

Goal

In our continuous endeavor to invigorate discussions within the German scientific community, our primary objective was to bridge the gap between budding researchers and established life science experts from both academia and industry. By contributing to BIOspektrum, we aimed to shed light on the innovative strides being made by young scientists, particularly in the realm of synthetic biology.

Our collaboration

BIOspektrum is a highly respected scientific journal that offers a wealth of information for those interested in the latest developments in molecular biology, biochemistry, microbiology, genetics, and developmental biology. It is published every two months in collaboration with esteemed bioscientific organizations and has a readership of over 15,000 science enthusiasts. We are excited to collaborate with this prestigious platform, as it allows us to share our passion for synthetic biology with a wider audience.

Article

In the journal's fifth issue this year, we took the privilege to curate a dedicated article spotlighting the German iGEM teams that graced this year's iGEM Challenge. The innovative and groundbreaking projects presented by these teams captured our attention and demonstrated the vast potential and flexibility of synthetic biology. We see these projects as evidence of the future of life sciences, led by the upcoming generation of scientists.

Acknowledgment

We extend our heartfelt gratitude to the BIOspektrum editorial team for granting us this invaluable platform. Their support has enabled us to contribute meaningfully to the German life science narrative. For those who wish to delve deeper into the topics discussed, the compendium of articles is available at this link .

Special thanks to Jonas Westphal, Lisa Siemers, Fanny Ott, and Maren Hinz for writing the article.


Where Science Meets The Slam Stage

In the dynamic world of science, events that promote the exchange of ideas and research results are invaluable. A science slam is one such forum that provides a stage for young researchers to present their work in an accessible yet academic setting.

Goal

The main goal of the Science Slam was to highlight the importance of excellent science communication while emphasizing the impressive contributions of student-led research teams. The goal was to translate complex scientific concepts into understandable yet profound presentations that would appeal to both experts and laypeople.

Our Collaboration

Our participation in the Science Slam was made possible by the ISA of the University of Hamburg, an initiative that promotes interdisciplinary study programs and supports the exchange between different scientific disciplines. Through this collaboration, we were not only able to present our research, but also to benefit from the findings and experiences of other researchers.

Science Slam

During the slam, we had the opportunity to describe our ongoing research projects in detail. But a particular highlight was the dialogue and interaction with other speakers working on new solutions to global challenges. This synergy emphasized the value of mentoring and idea sharing and fostered a culture of mutual respect and learning.

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Fig 11: (l) Special thanks to Andrea Köthe for preparing and giving the presentation./ (r) Team BioBits® and Team iGEM Hamburg 2023.
Take Home Message

In conclusion, the Science Slam was much more than a presentation of research. It was a celebration of the spirit of inquiry, teamwork, and the relentless pursuit of knowledge. It reminded us that science doesn't just happen in the lab, but also in the conversations, discussions and collaborations that inspire it.

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VAAM conference

The sharing of knowledge and experiences is yet another unique opportunity provided by participating in scientific conferences. This allows researchers to present their findings, learn from experts, and establish valuable connections within the scientific community. The VAAM Conference serves as such a forum, promoting scientific information exchange and the implementation of microbiological research outcomes for the benefit of society and the environment since its inception in 1985 in Würzburg.

Goal

An integral part of VAAM's history is providing a platform for students to showcase their scientific research through posters or presentations. By participating in a scientific conference, we aim to present our project, transFERRITIN, to the scientific community through (poster) presentations and to expand our network. A particular emphasis is placed on soliciting feedback, refining ideas, and disseminating our findings.

Our collaboration

Invited by The Association for General and Applied Microbiology VAAM through Prof. Dr. Jörg Stülke, we had the opportunity to attend the Annual Conference 2023 from 10 - 13 September 2023 at the Georg-August University in Göttingen. Here, we had the chance to engage in discussions on the following key topics: Regulation and Signal Transduction, Biotechnology, Computational Microbiology, and Fungal Interactions.

Science Landscape

The presence of microbiology experts at the conference not only afforded us invaluable insights into current research but also provided an opportunity for direct engagement with the speakers. Through these interactions and the diverse array of presentations, we were able to broaden our knowledge base and receive significant guidance and support. We extend our sincere gratitude to all our interlocutors for these enriching exchanges.

In addition to the academic discussions, the conference also served as a platform for representatives from various biochemistry companies to showcase their latest devices and methodologies. This facilitated dialogues with these enterprises, allowing us to learn more about their offerings and share details about our own research and the iGEM initiative. Many of these corporations are already patrons of iGEM teams, eagerly awaiting the innovative ideas presented by students each year. For those unfamiliar with iGEM, the conference was an avenue to gain insight into the program and express interest in potential future collaborations.

Lastly, we'd like to direct attention to the detailed list of participating iGEM teams and their projects, accessible via the provided link. Engaging with other iGEM teams proved invaluable, and we eagerly anticipate reconvening with many of them in Paris.

Take Home Message

The VAAM Conference was more than just an event; it was a nexus of knowledge, collaboration, and innovation. By delving into the latest research trends, engaging in meaningful dialogues with industry experts, and showcasing our own findings, we not only expanded our horizons but also fostered potential collaborations for future endeavors. The presence of representatives from leading biochemistry firms further enriched the experience, offering a glimpse into the cutting-edge tools and methodologies shaping the future of microbiology. Such synergies underscore the importance of collaborative platforms like the VAAM Conference, where shared knowledge and resources can catalyze groundbreaking initiatives. We are deeply grateful for this enriching experience and look forward to leveraging the insights gained for the advancement of science and society.

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European Meet-Up

Junior Jam - The European Meet-Up was a thrilling event hosted by iGEM Muenster. It spanned an entire weekend filled with captivating talks, interactive workshops, project presentations by iGEM Teams and fun activities.

During this event, teams had the opportunity to hone their presentation skills in preparation for the Grand Jamboree in Paris. They also engaged in valuable feedback sessions on their projects, all while fostering a stronger sense of community.

Our collaboration

Junior Jam 23 was hosted by iGEM Muenster from Aug. 4th 15:00 to Aug 6th 16:00 2023 in the Castle of Muenster. Each team was asked to prepare a 15 - 20 min presentation on their projects as well as a project poster. Food and beverages as well as all activities and presentations were organized by iGEM Muenster.

Program

The program began with a warm welcoming by iGEM Muenster inside of the castle of Muenster, followed by the introduction to the Junior Jam and its program.

Friday, 04.08.2023

The program started with an engaging talk from Prof. Jochen Schmid, an expert in Biotechnology, who delved into the boundless possibilities of Synthetic Biology. Following that, Sonja Billerbeck, a former iGEM participant, shared insights into her research in yeast and its application in synthetic biology. Succeeding the talks, each team had the chance to introduce themselves and provide a brief teaser of their project.

The Day ended with a Barbecue and a game of „Find a person who…“ Bingo. This game encouraged participants to interact with members of other iGEM teams you would have to find a person of different iGEM teams who has a trait that was written in the boxes. It was a great way to encourage interaction and build a sense of community.

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Fig 12.: (l) Junior Jam - European meet up. Barbecue and „Find a person who…“ Bingo./(r) The Bingo and the traits needed. We had the first Bingo of the day.
Saturday, 05.08.2023

The second day was dedicated to project presentation. After a brief greeting by iGEM Muenster, they announced that attendees could vote for the best presentation, with the winning team earning a ticket to a conference hosted by the German Association for Synthetic Biology (GASB), which was introduced later in the day.

Then the presentations began, with a total of 19 teams showcasing their exciting projects!

Apart from the project presentations, Andreas Möglich delivered a scientific talk on photobiochemistry and attendees were introduced to GASB. In the afternoon, participants engaged in discussions about their projects during the Poster Session.

Following the last presentation, the day concluded with a well deserved visit to the Bar - Davidwache. We had the chance to continue our conversations about our projects and the possibilities of Synthetic Biology and get to know each other better.

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Fig. 13: (l) Andrea, Joel, Lisa and Malcolm presenting our project at the Junior Jam 2023. /(r) Joel explaining the details to our project during the Junior Jams poster session.
Sunday, 06.08.2023

The final day of the Junior Jam began with two Workshops: „How to pitch your start-up“ and „From Science to start-up“. These workshops provided valuable insight into pitching ideas and potential futures for projects. Each year teams generate extraordinary ideas, that have resulted over 150 start-ups! During the workshops, we gained insights on how we might be able to develop our own start-up and pitch them effectively, and even developed our first business model (Fig. XX).

After the workshop, iGEM Muenster delivered the closing words and announced the winners for the best presentation - Team Hamburg with transFERRITIN!

A pleasant surprise, amit’s such high caliber projects and presentations.

Following the last presentation, the day concluded with a well deserved visit to the Bar - Davidwache. We had the chance to continue our conversations about our projects and the possibilities of Synthetic Biology and get to know each other better.

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Fig. 14: (l) Lisa working on our business./ (r) Andrea, Joel, Lisa and Malcolm won the prize for best presentation for iGEM Hamburg at the Junior Jam 2023.

Take Home Message

The meet-up was an exceptional opportunity to connect with like minded individuals. We had a fantastic time and the privilege of meeting remarkable people. We express our gratitude to iGEM Muenster for organizing this exceptional event and to the teams that voted for us! We eagerly look forward to see you all again at the BeNeLux-Germany Mini Jamboree and, of course the Grand Jamboree.

We wish you all the best of luck for your projects!


Game Experience with iGEM

We knew from the start that we intended to make our project transFERRITIN accessible to a wide audience as part of our public relations efforts. Our goal is to present science in a way that is simple, intriguing, and entertaining. We want everyone, regardless of their degree of science knowledge or opinion, to be able to grasp what we're doing here. We hope to serve as a link between difficult science and people of all ages.

For us, one of the best methods to achieve this is through games. Through games, we can break down complex content in an understandable manner and embed it in a context that is not intimidating but inviting. Therefore, we have engaged deeply in the development of our games and are very proud of what we have achieved.

The numerous events within the framework of public engagement have consistently demonstrated that our games achieve exactly what they are meant to. They provide every player with easy access to our complex scientific topic while simultaneously ensuring fun and enjoyment. This is exactly how it should be because learning is always much more enjoyable when you don't even realize that you are in the process of learning something. Enjoy exploring our games!

Interactive Web-App For Antibiotic Resistant Bacteria

Antibiotic resistances are a global problem that is not adequately perceived by many people.

Goal

Our aim is to raise awareness of this issue. Therefore, we began developing a game about antibiotic resistances. In our belief, problems can be better solved when they are understood, and one comprehends why a solution is necessary and how such a solution might look. Hence, we want to provide information with our antibiotic resistance game. We aim to illustrate how resistances develop, the methods and approaches that science has to counter existing resistances, and how bacteria, in turn, can react to scientific measures.

Our Collaboration

Following the meticulous crafting of our game template and its inaugural analog trial during this year's Girls Day, we transitioned towards realizing our aspiration of presenting the game as a digital web application. In this endeavor, we were privileged to collaborate with Floyd Wagner and Dario Krützkamp., who adeptly translated our game concept into code. We extend our profound gratitude for their seamless and professional partnership, which greatly enriched our project.

Why?

In our game, there is an interplay between the bacterium and the scientists until science, through new insights and literature research, arrives at new solutions, including our own idea: transFERRITIN.

By referring to our own project, we have the opportunity to delve into our idea within the game and explain why we consider transFERRITIN to be a promising solution. A glimpse into our research suggests that our modular drug delivery system could be a solution to antibiotic resistances. Perhaps, we can channel medications past the resistance mechanisms of bacteria and thereby destroy bacteria from the inside.

Simultaneously, it was essential for us to showcase various methods of bacterial resistance formation and the diverse possibilities of science. We wanted players to choose their own path from many options to understand the consequences of their actions. Despite the numerous paths and potential setbacks, the game is designed so that science ultimately prevails.

We sincerely hope that this holds true in real life!

Game Instruction

Hello and welcome to the Antibiotic Resistance Game by the iGEM Team Hamburg 2023. We are excited to welcome you to the world of bacteria and antibiotics! Before we dive into battling bacteria, let us introduce ourselves: We are a team of 15 students from Hamburg, Germany participating in the largest international competition for synthetic biology: iGEM. iGEM stands for the "international Genetically Engineered Machine competition”. We are competing against more than 400 teams from over 40 countries. Despite the term "competition," we are not fighting against each other, but rather together. We are all fighting for a better world, using synthetic biology as our weapon. If you haven't heard about synthetic biology before, no problem! We will still have fun together, and we'll tell you everything you need to know, so don't worry. We will reveal more about the project we are working on during the course of the game. Just a little preview: we want to eliminate harmful bacteria. This is not a new idea in itself – there are already antibiotics which we can use to do so. However, harmful bacteria developed defense mechanisms against antibiotics, effectively outsmarting them. These defense mechanisms are called resistances and pose a significant problem. We have come up with something to overcome these defense mechanisms and fight the harmful bacteria.

But enough about us, let's talk about you now!

We want to team up with you to take down harmful bacteria (single-celled organisms). We will explore how bacteria can protect themselves and what the field of science has already done to counteract these defense mechanisms.

So, to the bacteria, get set, go! Let's take them down!

"In a cheerful mood, you enter your workplace building and are approached by a colleague.

She says, "Thank goodness you're here! A dangerous bacterium is roaming around, causing many people to fall seriously ill. The hospitals are overflowing, and the doctors are helpless. This bacterium is persistent. It seems unbeatable."

You hold a different opinion, saying, "I can handle this bacterium just fine." After all, you're not just any scientist – you're an expert in your field. You put on your lab coat. If you have long hair, you tie it up, and off you go to the lab, your workspace. In the lab, you find all the materials and equipment you need to combat the bacteria.

You quickly review the basics of bacteria in your mind:

Bacteria aren't all the same: there are differences among them. We have bacteria in and on our own bodies that help us stay healthy. These bacteria are the ones you want to protect, not destroy with antibiotics.

Then, there are harmful or dangerous bacteria that make us sick. They can invade our bodies and trigger severe infections. Those bacteria are your target. You want to annihilate them.

Additionally, you bring the image of a bacterium to mind:

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It has an outer shell (cell wall) and many smaller components inside. Their task is it to supply the bacterium with energy and facilitate its reproduction. Additionally, you're continually fascinated by the fact that bacteria are the oldest forms of life on our planet.

However, you also know that bacteria can be defeated. Antibiotics are a good and proven weapon against these single-celled organisms. Antibiotics can penetrate the bacteria's cell wall or disrupt the processes within the cell, causing the bacteria to die. You're also aware that bacteria have developed defense mechanisms to protect themselves against the attack of antibiotics. "Those annoying resistances," you think to yourself. Bacteria should really not be underestimated!

Your team has gathered around you. All of you are ready to face this single-celled organism as a team and work together to find a solution. So, you all get started and examine the harmful bacterium before you.

Regarding the Game

The game is played in rounds - first, the science takes its turn, followed by the bacterium's response. Be cautious, as the bacterium might mutate and evolve during the game!

Carefully read through the set of cards and choose an appropriate one to efficiently combat the bacterium.

The bacterium's goal is to: Stay alive.

The science's goal is to: Render the Bacterium harmless!

You want to play it? Find the Web-Application here!.Have fun!Best of luck and success!"


Triplet Game

The world of synthetic cell biology is fascinating and complex, often appearing challenging to access. In order to bring this exciting subject closer to a wider audience and better explain our own project transFERRITIN, we have decided to develop a game for synthetic cell biology: our Triplett Game.

Goal

The goal of the game is to show, in a rough and highly simplified manner, the potential impact of synthetic cell biology and where it finds applications. Our modularly designed Triplett Game allows exploration of various themes. One version of the game enables the creation of individual beings, coded by arranging amino acids on a prepared DNA strand, leading to many unique and creative entities.

Game Instruction

In our Triplet Game, 10 freely chosen amino acids can be arranged on a prepared DNA strand. Each unique arrangement of these amino acids encodes a different being. We have developed a sophisticated coding system to ensure that each sequence of amino acids results in a unique creature.

The game material consists of many individual parts that can be combined in various ways. Our created beings can inhabit 10 different habitats. In total, 400 body parts, 10 skin tones, 100 pairs of eyes, 10 eye colors, 100 hairstyles, and 10 hair colors provide an impressive variety of combination possibilities. In this table, you will find a detailed listing of all colors and body parts.

Hair color Hair Eye color Eyes Skin color Head Torso Arms Legs Habit
blond short yellow human medium human (m) human (m) human (m) human (m) city
black medium black spider dark human (w) human (w) human (w) human (w) country
brown long brown goats tenned humen (d) humen (d) humen (d) humen (d) cave
gray curly gray blind gray pig pig pig pig beach
white Dreadlocks white cats light wolf wolf wolf wolf forest
turquois bald turquois non albino elephant elephant elephant elephant underwater
orange feathers orange Cyclops green alien alien alien alien air
blue spikes blue Frog purple bird bird bird bird space
green Horns green Snail red octopus octopus octopus octopus lava
red Afro red Chameleon blue lizard lizard lizard lizard snow

Memory

In our efforts to present iGEM in a creative and understandable manner, we quickly realized that at events where no lectures or presentations were planned, explaining iGEM posed a challenge. The solution through a poster seemed too conventional and unappealing. In our efforts to present iGEM in a creative and understandable way, we quickly realised that a poster or presentation looks too uncoventional and unattractive. In order to raise awareness of scientific projects and international competitions and at the same time generate enthusiasm for them, we decided on a creative solution: the iGEM Memory - a game for children from 0 to 99+.

Goal

The goal of the game is to find as many matching pairs of cards as possible by revealing two cards with the same image. iGEM Memory can be played in three different difficulty levels: Either matching image cards need to be found, or image cards need to be combined with matching text, or matching text cards need to be found.

Game Instruction

iGEM Memory consists of a set of 32 cards, with the option to decide which of the game variants to play based on the age group. Thus, iGEM Memory has a total of 16 image and 16 text cards. Regardless of the variant, 8 card pairs are always needed, resulting in a total of 16 cards. Shuffle the 16 cards well and place them face down on the table. Optionally, you can arrange them in a 4x4 grid.

Memory can be played either alone or against each other. At the beginning, the first player reveals two random cards. If the two revealed cards are identical, the player gets to keep those card pairs and flips two cards again. If the cards are not identical, they must be turned back over at the same positions, and the next player takes their turn. If you are playing Memory alone, you are back in play after revealing two different cards. The game continues until all card pairs are found. The winner is the player with the most found card pairs. Enjoy the game!


The Road Ahead

Reflecting on our journey, it's evident that while our primary goal was to nurture budding scientists, we too have grown immensely. Our competencies in project management, stakeholder communication, and pedagogical strategies have been honed. More importantly, we've come to realize that education is a two-way street. While we set out to teach, we ended up learning just as much, if not more, from our interactions with these curious minds. This experience has reinforced our belief in the transformative power of education and the potential it holds to shape the future of science.

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