Human Practices

Our second step towards integrating society into research was to acquaint ourselves with the diverse individuals who practice and study science. Our aim was to connect with people from different backgrounds, which led us to conduct interviews with scientists who have disabilities (PWD - People with Disabilities).

We had the tremendous opportunity to converse with Professor José Otávio Motta Pompeu e Silva, who is diagnosed with Autism Spectrum Disorder (ASD) and teaches the interdisciplinary course "Maps: Unraveling the Mind and Space," focusing on the well-being of over 800 students from various courses at UFRJ (Federal University of Rio de Janeiro). Following the interview, the professor invited us to lecture in the course and present on biotechnology and synthetic biology. Another collaboration with the professor was to connect him with the iGEM USP-EEL team.

We also interviewed scientist Nuccia Nicole Theodoro De Cicco, who has bilateral profound deafness with communicative ability in Brazilian Sign Language (Libras). She is the coordinator of the "Ladics UFRJ" Extension Project, which teaches science to deaf youth, providing accessibility to science.

Furthermore, we sought to democratize science through our social media platforms, primarily on Instagram and YouTube. We utilized these platforms to widely disseminate information about synthetic biology and, above all, science, making it accessible to everyone, from academics to the general public.

Entrepreneurship

Entrepreneurship is a dynamic field that demands not only innovation but also a solid business strategy. At the beginning of our venture, we focused on creating a robust business model. To effectively communicate our proposal, we developed a detailed media kit outlining our mission, vision, and values. This material became our central tool for presenting our project clearly and convincingly.

During the validation process, we reached out to notable companies such as Biobreyer, P&G, and Merck. With Biobreyer, we had a valuable exchange of ideas. They shared insightful perspectives on product development stages, guiding us on how to enhance our sales approach, especially in clinical contexts. This guidance was invaluable, providing precise direction for our market strategy.

P&G, a global consumer goods powerhouse, offered a fresh perspective on how to sell and establish markets. Their insights helped us refine our sales and marketing strategies.

Merck initially provided valuable support to our project by supplying essential laboratory materials. Although subsequent contact did not materialize, we deeply appreciated the initial support we received.

These interactions with companies and partners taught us the importance of adaptation, continuous innovation, and the ability to swiftly adjust to market changes. Our entrepreneurial journey was enriched by these experiences, reinforcing our commitment to building a successful and sustainable business.

Another entrepreneurial initiative involves our collaboration with the Operon USP team. In December 2022, the iGEM-USP Brazil team was invited by Operon USP a Synthetic Biology Club at the School of Arts, Sciences, and Humanities of the University of São Paulo, which was in its formative stage. In this entrepreneurial context, Operon USP sought assistance from the iGEM-USP Brazil team for the administrative and structural planning of the club, as well as for defining themes for the meetings scheduled for 2023. Our team recognizing the importance of entrepreneurship in academia, so we shared our experiences and knowledge, providing crucial guidance for the formation of the club.

During this collaboration, not only internal organization strategies for Operon USP were explored but also possible partnerships and joint projects between the two academic entities were discussed. In a broader context, our team emphasized the significance of an active synthetic biology club to attract and nurture future members, who could represent Brazil and the university in upcoming entrepreneurial competitions.

Last but not least, we were invited to present our project in the Synthetic Biology module at CEPID B³ (Center for Research on Bacteria and Bacteriophages Biology), with the possibility of regular participation. Specifically, we would be involved in CEPID B3, which focuses on investigating virulence factors and bacterial resistance against antibiotics, as well as proposing new molecules with clinical potential. This collaboration represents a valuable opportunity for us, we would receive mentorship from respected professors in the field of microbiology and the chance to enhance our knowledge in this area. Additionally, we could share our findings with other teams, contributing to the scientific community.

However, we believe this was just the first step in popularizing synthetic biology in society. One of our significant educational initiatives is the Brazilian Synthetic Biology Olympiad (OBBS), where the company Fractal provides technical support. Fractal is responsible for the online platform of OBBS and conducts the competition's examination nationwide. This collaboration has been crucial in strengthening our online presence and expanding the competition's reach, allowing more people to participate and engage with the field of synthetic biology.

The dissemination of Synthetic Biology plays a crucial role in education, and our group has been wholeheartedly committed to this cause. Over time, we have developed a series of projects ranging from formal education to raising awareness in society at large. The main objective of these initiatives is to spread knowledge and understanding of Synthetic Biology. With projects like the Brazilian Synthetic Biology Olympiad (OBBS), the "Biology on the Street" initiative, and the scientific camp at schools, we are dedicated to engaging students, teachers, and the general public in a constructive dialogue about the possibilities and challenges of this innovative field.

The dissemination of Synthetic Biology plays a crucial role in education, and our group has been wholeheartedly committed to this cause. Over time, we have developed a series of projects ranging from formal education to raising awareness in society at large. The main objective of these initiatives is to spread knowledge and understanding of Synthetic Biology. With projects like the Brazilian Synthetic Biology Olympiad (OBBS), the "Biology on the Street" initiative, and the scientific camp at schools, we are dedicated to engaging students, teachers, and the general public in a constructive dialogue about the possibilities and challenges of this innovative field.

Step by Step through Science Education

The Brazilian Synthetic Biology Olympiad (Olimpíada Brasileira de Biologia Sintética/OBBS) is a pioneering initiative that emerged from our Let it Bee project in 2021. Recognizing its untapped potential, we were determined to expand its reach and impact across Brazil. Tailored for high school students nationwide, what sets OBBS apart is its inclusive approach — no prior knowledge beyond the standard high school curriculum is required. Through an investigative teaching methodology, participants not only take an exam but embark on a journey to grasp the foundational principles of synthetic biology, biotechnology, and molecular biology. This practical understanding enables them to appreciate the real-world applications of synthetic biology, bridging a crucial gap often left unaddressed in traditional classroom settings.

But OBBS is more than just an online exam. It's a journey of discovery and empowerment. Our top performers are rewarded with an immersive experience in synthetic biology, engaging with cutting-edge concepts and methodologies right from their own homes.

The impact of OBBS extends far beyond the virtual learning environment. We receive overwhelmingly positive feedback from participants, many of whom initially had little or no exposure to synthetic biology. Countless testimonies attest to their newfound fascination, with some now considering academic pursuits in related fields. We've been approached by participants eager to form iGEM teams and delve deeper into the world of synthetic biology, showcasing the profound influence OBBS has on igniting scientific passion.

Championing Inclusivity: In Brazil, educational opportunities often hinge on whether one attends a public or private school. Private institutions typically offer extensive courses in biology, physics, and chemistry from middle school onwards. In contrast, public schools often provide more limited coverage, reducing these subjects to a generalized 'science' curriculum in high school. This divide exacerbates existing challenges in ensuring equitable access, particularly for marginalized groups facing the deeply ingrained issues of structural racism and xenophobia in Brazilian society.

This year marks a major milestone. We've substantially increased participation from public schools, affirming our commitment to inclusive education. Over the past three years, we've meticulously analyzed student engagement in OBBS across both public and private schools, providing invaluable insights into its impact on diverse educational backgrounds. Our outreach strategy has cast a wide net, resulting in a rich tapestry of student representation. The forthcoming 'OBBS Participation by School Type' graph will vividly illustrate this comparative perspective.

We've also made remarkable strides in promoting gender inclusivity. This year, approximately 60% of OBBS participants are female. This is an encouraging trend, as it indicates that OBBS is providing a platform for young women to explore and excel in the fields of synthetic biology, science, and technology — areas where they have been historically underrepresented. We believe that fostering this inclusivity is not only a testament to OBBS' commitment to equality but also an essential step in driving progress and innovation in these fields.

Our ongoing collaboration with various Olympiads, organizations, and institutions underscores our dedication to accessibility. Through this dynamic exchange, we've gained invaluable insights into OBBS' format, administration, and promotion, making it ever more inclusive. For instance, our dialogue with the Brazilian Biology Olympiad (OBB) was instrumental in mentoring on accessibility, organization, and promotion.

This approach allows us to closely examine the progress of students, contributing to a more equitable access to educational opportunities. It's a testament to OBBS' unwavering commitment to leveling the playing field and empowering students from all walks of life.

In 2023, OBBS received an astounding 4,000+ registrations, demonstrating the growing interest and impact of our initiative. This surge in participation further reinforces our belief in the power of inclusive education to inspire the next generation of scientists.

The success of OBBS is not achieved in isolation. It is the result of a collective endeavor, brought to fruition through the combined efforts of educators, schools, students, iGEM teams, synthetic biology clubs across Brazil, and our esteemed partners at the Vertere Institute, a non-profit organization affiliated with Fractal, a distinguished company in the realm of digital learning. Their invaluable contribution includes hosting and providing the online platform that facilitates the Olympiad. It is through this extensive network of collaboration that we are able to extend the reach of OBBS, ensuring its accessibility to a diverse array of students across Brazil and impacting the lives of thousands of Brazilians through synthetic biology!

Furthermore, with the aim of broadening students' access to science, we established the Scientific Camp: an event specifically tailored for students within the age range of 12 to 15 from public schools. This choice was motivated by the goal of providing these students with a fundamental understanding of science concepts, empowering them to participate in the OBBS exam should they choose to pursue this path. Additionally, the camp was designed to foster the development of both hard and soft skills essential for their educational journey and future endeavors in the field of science.

The decision to target public school students was driven by the identified need. Additionally, we selected a school in close proximity to our university. Often, students perceive our university as a park due to its extensive green space and limited information accessibility. Similarly, many students hold the misconception that public universities in Brazil require tuition fees, whereas they are a right for every Brazilian citizen.

To generate engagement and interest, we incorporated inclusive teaching techniques, with a particular focus on gamification.

In 2021, we held the inaugural edition of this event remotely (due to the pandemic) with the Let.it.Bee project by Team iGEM USP-Brazil 2021 . This edition concentrated on developing soft skills and structuring activities spanning a week, each lasting a day. However, as they were online activities, students didn't have as much freedom of choice to carry out them because the activities and the narrativa were designed by videos. Therefore, some students couldn’t getting much help readily. Positively, this edition helped to reduce school dropouts during the pandemic, beside that, the students learned aspects of biology, physics and chemistry.

Upon the return to in-person activities in 2022, a reshaping of the event's goals and approaches was essential, we concentrated on organizing dynamic activities collaboratively and interdisciplinarity. In this year, after the initial arrangement, we compiled the activities developed and organized them around a common theme, based on student feedback obtained through a survey regarding their preferences and interests in cultural products. From there, we crafted a narrative centered on "learning while having fun" employing the following steps: 1. purpose; 2. means; 3. objective; 4. motivators; 5. prototype; 6. management and production; 7. feedback (for future improvements).

Located in Vila Dalva, the Samuel Klabin State School, it was the place that embraced our innovative approach. In its second edition, the gamification method was intensified through the creation of groups and the introduction of thematic stations. These stations offered adaptable storylines and multiple pathways for children to explore, covering themes such as microbiology, health, hygiene, and fundamental concepts of cells and synthetic biology. This captivating narrative encouraged group discussions, inspiring children to work together to find answers and advance in their adventure.

We collaborated with the school principal to create an event that was accessible and inclusive for all students, to fulfill this goal, we developed these activities to use different tools as images, hands-on activities, also we used acting techniques to accommodate students who may not yet have developed reading skills.

Incorporating games and challenges to address children's everyday concerns creates a meaningful and hands-on learning experience. This approach fosters increased social engagement, promoting both collaboration and friendly competition among participants. It enhances teamwork and communication skills among students, rendering the learning process more captivating and interactive.

The event took place at the school , and based on the surroundings, we constructed scenes resembling local businesses, simulating a video game scenario, and effectively creating a real-life RPG (role-playing game). With a total of 67 children, they were divided into groups of "Guardians”, assisted by the staff-volunteer monitors from our university. They followed a pre-planned path through classrooms and the courtyard to make the adventure safer to all students, due to great amount of kids in the event.

The narrative unfolded across roughly four hours, with a new segment of the story being unveiled every 40 minutes. At the conclusion of each segment, iGEM, symbolizing an organization entrusted with safeguarding all of humanity's knowledge and possessing the information needed to save the world in this context, assisted the students in crafting hypotheses about the events that had occurred. This ultimately led to the unveiling of the Biobrick.

All materials used in the scenario were recyclable, reflecting our concern for the environment and the importance of demonstrating how materials can be repurposed. Additionally, we collaborated with individuals from other outreach programs (such as "Chemistry in Action" and "EB").

We received assistance from Maria Elisa, a member of the previous team, in the beginning of the planning.

This approach effectively aligned the methodology with the practical application, and we achieved our intended objectives, delivering numerous benefits to society.

The Scientific Camp project, which has already demonstrated its success over time, is poised for substantial expansion and enhancement in the future. Within this developmental framework, we plan to reach to a larger number of schools in diverse communities, to facilitate event replication, the project plans to create a comprehensive guide and developing a specialized training program for teachers.

In summary, the Scientific Camp is more than an educational initiative, it is a transformative space where curiosity is nurtured, collaboration is encouraged, and knowledge is cultivated.

Our project has showcased its capacity to align with the UN's global goals, marking significant progress not only in the realm of science but also in contributing significantly to UN objectives concerning Quality Education (SDG 4) and Industry, Innovation, and Infrastructure (SDG 9).

Through our human practices and our steadfast commitment to education, our initiatives have seamlessly integrated with the promotion of innovation and sustainable infrastructure. By actively engaging with the community, we've assumed the role of change agents, dedicating ourselves to creating a positive impact in our immediate environment and beyond. SDG 9 underscores the importance of developing sustainable technologies and infrastructures to drive economic and social growth. By fostering innovation, research, and development, we're pioneering solutions that not only enhance the quality of life but also diminish societal disparities.

In our human practices, we approached these projects mindful of ethical considerations and social responsibility. We prioritized needs and values, emphasizing social impact, and struck a balance between scientific objectives and societal concerns to ensure overall benefit for the society. This holistic approach not only reflects our dedication to making a meaningful difference but also underscores our commitment to a future that is both innovative and inclusive."