Education

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Introduction

It’s already well known the importance of education to the construction of a functional society. But it is exactly because this quote is so well established that a fundamental question is often left aside:

what sort of education?

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Even with a noticeable increase in the number of people aged 25 and older attending high school, the disparity in education remains significant.

This question highlights a significant problem in education: an emphasis on theoretical problem-solving instead of practical applications. Students often memorize content just to get good grades, without having ample opportunities to develop their creativity, reasoning, and real-world problem-solving skills. Our projects aim to transform this approach by promoting creativity, critical thinking, and a passion for synthetic biology. In this way, we believe that our project "Strep by Strep" not only addresses the urgent need for more meaningful education but also becomes an inspiring model for the future of learning, where scientific innovation and personal development harmoniously intersect, preparing future generations to face the challenges that await them with confidence and determination.

We are confident that our project "Strep by Strep" not only fulfills the important requirement for more valuable education but also sets an example for the future of learning. By combining scientific innovation and personal development, we prepare future generations to face upcoming challenges with confidence and determination.

Strep by Strep at Avenida Paulista

In Brazil, the spread of fake news is an alarming problem, with 4 out of 10 people claiming to receive fake news daily. In the world of science, the accuracy and reliability of information are essential, fake news can undermine trust in the scientific community, create fear and uncertainty in people, and, ultimately, harm public health.

How can we strengthen ties between science and society?

That was the central question that motivated the Synthetic Biology team from USP BR to hold the "Strep by Strep on Avenida Paulista" on June 8, 2023, and August 20, 2023. This event aimed to combat fake news and promote the Strep by Strep project to society.

The team members approached passersby on Avenida Paulista, inviting them to engage in a dialogue about news:

With 3 to 5 carefully selected news articles covering topics such as vaccines, medications, viruses, and bacteria, participants were challenged to determine whether these articles were true or false. After their responses, we explained whether they were correct and what is the scientific consensus regarding each topic. This activity was named "Fato ou Fake," or in English, Fact or Fake.

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During our interactions, we showcased the potential of Synthetic Biology to not only progress scientific research but also address the problem of fake news. We encouraged participants to become discerning individuals by verifying information before disseminating it, and they acquired knowledge about vaccines, medication usage, and bacteria.on usage, and bacteria.

The team came up with a clever way to spread the word about their project "Strep by Strep" to the community. They crafted a fictional gossip story that revolved around a well-known individual who was rumored to emit the smell of rain when their skin came into contact with water. However, they later revealed that this was all fabricated and clarified that the true source of the scent of rain is actually the bacterium Streptomyces olindensis. At this point, the team provided more information about our project and how it could positively influence society.

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SynBio and Culture

The integration of scientific themes in dystopian and fantastical tales has surged alongside advances in biology and natural sciences. Films like "Dr. Jekyll and Mr. Hyde" (1931) and "Frankenstein" (1931) popularized science in a fantastic yet dangerous light, exploring the limits of human abilities.

Synthetic biology events provide a valuable opportunity to engage the public in contemporary scientific challenges amid complex issues like climate change and epidemics. Understanding science is essential for informed decision-making, as emphasized by the UNESCO Science Literacy Report.

These events cultivate a skilled science and technology workforce and dispel societal stigmas about science. Therefore, Synthetic biology events not only enhance scientific literacy but also shape contemporary sociocultural dynamics. They empower individuals to tackle intricate scientific and technological issues, transcending societal stigmas and nurturing future world-changers.

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Scientific Camp Journey

In 2021 and 2023, the success of the event was remarkable, leading to lower school dropout rates among the participants and increased classroom interaction, as reported by the teachers of Samuel Klabin State School, located in Vila Dalva.

The methodology of gamification was enhanced in the second edition with the formation of groups and the development of thematic stations, offering adaptable narratives and diverse paths for children to explore. The themes covered included microbiology, health, hygiene, and basic concepts of cells and synthetic biology, all within a challenging narrative that promoted group discussions for children to arrive at answers together and advance in the adventure.

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Pedagogical Event Planning

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Target Audience

The target audience of the project is middle school students. During this period, students acquire more complex and critical thinking skills, becoming capable of understanding and interacting with scientific concepts more effectively. It also represents a transition in the educational trajectory of the students, as they will move on to high school.

The strategic choice to carry out the Scientific Camp in public schools aims to democratize access to high-quality scientific education and reduce disparities between public and private education, bringing educational equity.

Gamification Methodology

We use Gamification which, according to Peter Jacson, is a structured process that uses game elements to engage and motivate people.

1) Develop a clear objective that incorporates relevant game elements

2) Define a final goal.

3) Use motivators to reward progress

4) Create prototypes to test and bring refinement

5) Implementation of the strategy

6) Collect feedback for continuous improvements

So, the development of the event is done in conjunction with the school, taking into account both the specifics of the physical space and the profile of the students, to create an accessible event that can include even those who have not yet been literate, through the development of dramaturgy and the use of images. From there, a narrative script is created that includes the elements of the local landscape and the surrounding area of the school, simulating a video game, and later developing into scenarios.

On the day of the event, the scenarios are built and the children are divided into groups, assisted by the staff and volunteer monitors from the university itself, following a pre-planned path according to the script. In this context, it is important to emphasize that preference should be given to the use of recycled materials for the creation of the environment, to reduce environmental impact and raise awareness among the children to adopt a sustainable attitude.

Gamification stands out in this aspect, providing challenges, rewards, and playful elements that encourage active student participation, placing them at the center of the learning process, and encouraging them to solve problems, make decisions, and explore concepts, which stimulates critical and investigative thinking.

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The event: "Step by Step: Scientific Camp"

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"The year is 2123, and human civilization collapsed a century ago due to a combination of natural and human-made factors, leaving it vulnerable to a terrible disease. Fragmented by conflicts, society couldn't respond to this new threat. Before the end, a group of people from diverse backgrounds joined forces with iGEM USP to leave a message and technology for the future, for when there was an opportunity to start anew. These records were discovered by the Guardians and are now passed on to you, the Chosen Ones."

This marked the beginning of the Scientific Camp in 2023, held at Samuel Klabin State School for middle school students, with the participation of 67 children, and the total duration was 4 hours, with a new part of the journey revealed every 40 minutes. The Scientific Camp collaborated with the school and university extension projects like Chemistry in Action and Biology Station.

The narrative portrayed a post-apocalyptic world caused by a superbug outbreak, emphasizing the importance of creating new antibiotics and using them responsibly.

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The camp featured interactive stations, each connecting with the post-apocalyptic narrative. During the implementation, there were both actors (playing characters from the narrative and guiding the activities) and staff members (performing tasks behind the scenes, as well as taking care of cleaning and food).

Below is a brief summary of the activities performed at each of the stations and their context in the narrative.

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After the introduction to the story, the students were divided into four teams, each guided by one of the Guardians, members of the order that had discovered the iGEM* message. Each team had to go through five stations and there was no particular order, except for the Market and the Tool Store, which were accessed sequentially.

*iGEM: In the activity, iGEM was an organization that compiled information to find a cure in the future

In the Market, the DNA extraction experiment from fruits was performed with the assistance of the Biology Station (in the context of the story, holograms of past members teaching the procedure).

In the Tool Store, the teams encountered the RiboBot, an android left by iGEM, which "analyzed" the DNA of the fruits and presented a message encoded in "ATCG" for the students to decipher.

translated message (both in the literal sense and imitating the process of translation carried out by the ribosome) reads as follows (translated from Brazilian Portuguese): "I am the DNA. Everyone has me. I teach the cell to assemble life. I can be changed and build something new. Study the cell, bacteria, and viruses."

At the Abandoned Hospital station, participants encountered a mad scientist who had lost his sanity after witnessing society collapse in the face of the spreading disease, despite his efforts to raise awareness of the risks and prevention methods. Before helping the students on their journey, the doctor insisted that they play the board game "Bacteria and Antibiotics," developed by the iGEM USP team for a previous event. This station was used to address topics related to misinformation, hygiene, correct use of antibiotics, and the risks of superbugs.

At the Biology Laboratory station, the students encountered a Guardian who arrived early to study the area. With his guidance, they played the game "Collective Immunity", developed by the Butantan Institute, exploring the themes of disease spread, vaccination, and herd immunity. Additionally, after the game ended, participants also found cardboard models of prokaryotic and eukaryotic cells, allowing them to explore their components and structure in three dimensions.

At the Microscopic Environment station, the students followed (or started, if explored earlier) the approach the cellular area. Under the narrative pretext of a magical creature shrinking them with a potion, participants explored the inside of the cell and the functioning of antibiotics, discussing with their mysterious host what they had learned after the activity.

After all stations were completed, the teams were gathered for the final area. At the conclusion of each previous activity, each group had received a strip of paper with a piece of a message, which they could now assemble to read:

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With the password, students gained access to the final station: the University, where they were welcomed by StreptoBot, another android left by iGEM, who led the activity. Before proceeding with the games, however, the robot summarized the story so far and tested the participants' knowledge, as well as spoke about the role of free public universities and extension projects, aiming to motivate the students to consider enrolling at USP, a free university in their real-life future.

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The final challenge was relatively simple, with representatives from the teams needing to work together to replicate a structure made of differently shaped wooden blocks. A photo of the correctly assembled structure was shown for ten seconds by StreptoBot, but in a monochromatic version, requiring students to deduce the correct colors based on the shapes of the pieces. After their success, the robot took the assembled structure to a biological reactor capable of producing a new antibiotic from the "biobrick" formed, opening a path to restore civilization. The activity was concluded, and snacks were served to everyone.

Future Perspectives

The project of the Scientific Camp, which has already proven to be a success in its trajectory, is looking towards a future of significant expansion and improvement. In this development horizon, some specific goals have been outlined:

+ Expand the reach of the Camp, extending it to a greater number of schools in diverse communities and including basic education levels.

+ To facilitate the replication of the event, the creation of a guide is being planned with detailed information about the gamification methodology, practical activities, necessary resources, and guidelines for conducting the Scientific Camp.

+ The project also aims to develop a specialized training program for teachers. This will adequately prepare them to effectively carry out the event, ensuring that the pedagogical objectives are achieved and that students have an enriching educational experience.

These future perspectives reflect the ongoing commitment to promote quality scientific education, making it accessible to a wider audience, and positively inspiring the future generations of scientists and citizens.

The project continues its inspiring journey towards a future full of discoveries and learning.

Brazilian Synthetic Biology Olympiad (OBBS)

The Brazilian Synthetic Biology Olympiad, known as Olimpíada Brasileira de Biologia Sintética (OBBS), was founded in 2021 as a legacy of the Let it Bee project. Recognizing the untapped potential of this initiative, we aimed to extend its impact to a wider audience across Brazil. Targeting high school students nationwide, OBBS distinguishes itself by not requiring knowledge beyond the regular high school curriculum. Through an investigative approach, participants have the opportunity to grasp the fundamental concepts of synthetic biology, biotechnology, and molecular biology, enabling a practical understanding of the applications of synthetic biology. In this way, OBBS fills a gap in basic education by promoting an understanding of synthetic biology, an area often absent from classrooms.

Since its debut in 2021, OBBS has received support from the Ministry of Science and Technology. In its second edition in 2022, it maintained the number of student registrations from all Brazilian states. In the third edition in 2023, we successfully achieved the goal of expanding its visibility and accessibility, especially for students from public schools.

OBBS

One of the main focuses since the inception of OBBS has been to ensure that the exam reflects the educational reality of the country, where deficits are often found, especially in the sciences. OBBS aims to introduce and encourage high school students to explore the world of synthetic biology, a field often absent from the school curriculum. To achieve this, the approach is to provide as much information as possible in the questions, allowing students to learn while taking the test. This distinctive approach is what has earned OBBS such positive feedback from students - through logical-interpretative reasoning, participants accumulate knowledge that enables them to address specific issues in the field of synthetic biology, maintaining the level of challenge and competitiveness characteristic of a knowledge competition.

To learn more details about the origin of OBBS, check out this section of our WIKI from the Let.it.bee project.

How Does OBBS Work?

OBBS consists of two phases: the first one comprises 20 multiple-choice questions on general biology, and the second phase consists of 15 more in-depth questions on synthetic biology. Both phases take place online, providing participants with the flexibility to complete the exam within a 7-day period after the questions are released on the virtual platform. The exam can be taken using computers, tablets, and mobile phones.

Fractal, a company specializing in digital learning, and the Vertere Institute, its non-profit arm, are our partners. These two entities collaborate with us in hosting the platform where the online exam is conducted.

OBBS workflow

Achievements

In our dedicated effort to kindle nationwide interest in the Olympiad in Biological Synthetic Biology (OBBS), we embraced an inclusive approach, welcoming students from all educational backgrounds. Our outreach spanned public and private institutions across Brazil. The 'OBBS Around Brazil' figure exemplifies this collective engagement, showcasing students' dedication in diverse academic settings, illustrating the universal appeal and influence of OBBS. Their participation serves as a testament to the universal appeal and impact of OBBS within the broader educational landscape.

OBBS around brazil 2023 Explore data from previous years to witness the continued growth and impact of OBBS! OBBS around brazil 2022 OBBS around brazil 2021

As part of our ongoing commitment to fostering interest and participation in the Olympiad in Biological Synthetic Biology (OBBS), we've diligently tracked students' performance in the first phase over the course of three years. The histograms below offer a visual representation of this data, illustrating the progression and achievements of participants. By analyzing performance trends, we gain valuable insights into the evolving landscape of OBBS and its impact on students' academic endeavors.

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Explore the performance trends of the first phase from previous editions!

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OBBS Feedback:

In the initial phase of the 2023 OBBS edition, we gathered data from more than 800 participants through a voluntary survey regarding their socio-economic conditions. This information offers valuable insights into a substantial portion of our registrants.

Below, three comments have been selected that encompass a range of perspectives, from the initial learning experience to the challenge and practical application of knowledge, providing a comprehensive insight into OBBS.

OBBS feedback

Following feedback from over 600 OBBS 2023 participants, we created a 'word cloud' to distill their responses. This visual representation succinctly captures the essence of their feedback. Noteworthy among the recurring words are: “opportunity, knowledge, enjoyed, learned, hope”. This reinforces our dedication to delivering a valuable and enriching experience through OBBS.

OBBS Mapa feedback

Popularization of OBBS

Since its inception, OBBS has experienced remarkable growth on social media. Currently, it has surpassed our team's official Instagram page in terms of followers, highlighting the scale and potential of the Olympiad. As an example, just in 2023, the OBBS Instagram page (@O_B_B_S) gained over 2,000 followers!

Below, you can find some insights about OBBS on Instagram, as provided in a report generated by Meta: OBBS audience

OBBS Special Prize - Synthetic Biology Immersion Week

The Synthetic Biology Immersion Week is an initiative aimed at providing students with a unique and immersive experience in the world of Synthetic Biology research and related fields. Our main goal is to inspire participants to deepen their interests in synbio and possibly consider a career in this field or related areas. To make this prize possible, we have the support of our University's Pro-Rectorate for Culture and Extension, which kindly granted us permission to use the logo, facilities, and financial aid from USP. This collaboration has been crucial for the success and continuity of this program.

Learn more about the OBBS Special Prize.

Since its first edition in 2022, OBBS has offered the Synthetic Biology Immersion Week as a special prize for students who excelled in the Olympiad. During this event, participants have the opportunity to visit specialized laboratories in Synthetic Biology, Biotechnology, and related areas, providing them with direct contact with the research environment. Additionally, various forms of integration at USP are presented, including opportunities offered by the university through extracurricular activities, extension groups, and academic leagues.

We look forward to the third edition of the OBBS Special Prize, scheduled for January 2024. We plan to further enhance the quality of the event, considering the implementation of a day of activities in the city of Campinas, where Sirius (Particle Accelerator) is located. Sirius, situated in Campinas, is the most extensive and sophisticated energy and materials research center in Brazil. This particle accelerator represents cutting-edge research infrastructure, with diverse applications in the field of biotechnology.

It is crucial for bright students to have the opportunity to witness the high level of research we have in our country. This experience can not only instill a deeper interest in synthetic biology but also ignite a passion for science in general. We encourage these young talents to explore and contribute to the advancement of scientific knowledge, and the Synthetic Biology Immersion Week is an amazing starting point for this journey.

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Reaping the Rewards

Recently, we received exciting news from a former participant of the Immersion Week who reached out to us after being admitted to a university. Upon encountering molecular biology subjects, he is filled with enthusiasm to form an iGEM team and start a synthetic biology club. We are committed to providing all the support and guidance necessary to turn this idea into reality. This experience is clear evidence of the lasting impact that events like the Immersion Week can have in promoting synbio.

Special Thanks

We would like to express our deep gratitude for the valuable partnership established with the iGEM USP-EEL team. Their contribution in creating questions for both stages of OBBS, as well as providing the synthetic biology handbook, which served as supplementary material for students during the exam, was crucial in enriching the exam content. This provided diverse perspectives, resulting in a more engaging and well-crafted test. Additionally, we cannot fail to mention the essential support offered by the UNILA team and the former participants of the Synthetic Biology Immersion Week. They have become true ambassadors in their respective regions, actively promoting OBBS.

We extend our thanks to the entire network of schools and educators who not only embraced the idea of OBBS but also enthusiastically promoted it. We also want to express our gratitude to the Vertere Institute, whose collaboration connected us with a group of coordinators from other Brazilian Olympiads, further expanding the event's outreach.

We are deeply pleased with the reach and excellent reputation that OBBS has achieved. This is largely due to the collaboration and generous support of everyone involved in OBBS.

Vision for the Future

We are committed to establishing international partnerships to expand the participation of students from across Latin America in future editions of OBBS. With this, we aim to disseminate not only the importance but also the fundamentals and applications of synthetic biology among students in our country and neighboring nations.

Furthermore, we are preparing to strengthen collaboration with synthetic biology entities in our country, with the goal of enriching the Olympiad's questions and providing an even more challenging and enriching experience for all participants. Together, we are shaping the future of synthetic biology and fostering intellectual growth and a passion for science throughout the region.

Conclusion

Through innovative teaching methodologies, collaborative learning experiences, and meaningful community engagement, our educational initiative aims to address societal challenges. By nurturing a new generation of thinkers, problem-solvers, and compassionate leaders, we aspire to create a ripple effect of positive change that extends far beyond the confines of the classroom.

Moreover, our project is not just an endeavor within the walls of an educational institution; it's a catalyst for social transformation. We actively seek partnerships with local communities to create a network of support for education. By involving stakeholders from various sectors, we ensure that our educational efforts are aligned with real-world needs and opportunities.

As we move forward, we renew our commitment to education as a powerful force for positive change. With determination and hard work, we are confident that our educational project will continue to inspire, empower, and open doors to a brighter future.

References:

https://www.cnnbrasil.com.br/nacional/4-em-cada-10-brasileiros-afirmam-receber-fake-news-diariamente/