Milk's Global Impact: Nutritional, Economic, and Societal Significance"

Besides its high nutritional value in the life of many people worldwide, milk provides more than 10% of the world’s nutrient availability. Dairy production is a significant industry globally, offering both economic and nutritional value. Milk alone accounts for about 8% of the world's total food production.1
Dairy farming is a widespread agricultural practice, with people milking dairy animals in nearly every corner of the globe. Remarkably, approximately one billion people reside on dairy farms.2

Why AureoBos?
AureoBos is set to revolutionize the dairy industry with its pioneering intramammary infusion treatment. By offering dairy producers an innovative solution for addressing bovine mastitis, caused by the four most common microorganisms - Staphylococcus aureus, Streptococcus agalactiae, Streptococcus uberis, and Escherichia coli - we eliminate the reliance on antibiotics. Our mission is to drive substantial reductions in milk wastage, make a positive impact on the environment, and eliminate the costly milk withdrawal period, translating into significant economic gains for the industry.
175 liters
Discarded liters of milk per cow treated with a 5 day antibiotic* *Information gathered from the interviews and visits conducted at Human Practices
How did we do it?
Based on synthetic biology, we have devised a plan to develop an alternative to conventional antibiotic treatments for bovine mastitis. This treatment involves endolysins derived from bacteriophages, which target the primary bacteria responsible for this bovine ailment.
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The design relied on utilizing specific endolysins from the microorganisms responsible for bovine mastitis, in conjunction with albumin binding domains. This resulted in the creation of novel fusion proteins with significant antimicrobial potential.
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Using the Golden Gate assembly technique, a protein expression system was constructed and introduced into a bacterial biofactory of E. coli BL21 (DE3) for the large-scale production of recombinant endolysins.
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To test the concept, bactericidal assays were conducted, facing up our recombinant endolysins against the bacteria primarily responsible for bovine mastitis. The tests were performed using ELISA plates and resazurin.
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Project Description
Human Practices

(1) Santos, Ana Sofia. “Milk Benefits: Should We Drink Milk?” Ruminants.ceva.pro, 2023, ruminants.ceva.pro/milk-benefits-should-we-drink-milk#:~:text=Dairy%20production%20is%20a%20major. Accessed 10 Oct. 2023.

(2) International Dairy Federation. IDF Factsheet – February 2013 Scientific Excellence Industry Applicability Strategic Networking Global Influence. 2013.

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