We are PARSE: PhAge deRived growth SEtters
Molecular biology workflow relies on the growth and maintenance of microbes...
...but the lack of control over how fast microbes grow can hinder some areas of research...
microbial co-cultures are highly unstable, protein production is held back by energetic flux shunted towards growth and giving directed evolving microbes an arbitrary growth advantage is nearly impossible!
Can microbial growth be controlled?
Yes, but not predictably. If a precise growth rate is required, changes to nutrients, pH, and temperature may not provide the fidelity with which to program it.
Can we predictably control bacterial growth?
Now you can! The Sheffield iGEM Fairies are back this year to bring you PARSE: PhAge deRived growth SlowErs - a set of genetic parts that allow for the tuning of bacterial growth with a range of potential inducers, alongside a bespoke turbidostat to ease the required experiments
This is why we built PARSE
Sheffield iGEM 2022, amongst other iGEM teams, have unearthed a key problem within the field of microbiology: how do we predictably control microbial growth? To tackle this, the science fairies from Sheffield iGEM 2023 have taken the first steps into granting this wish with PARSE. This year we’ve combined:
Hardware modelling and Systems Design and Engineering
Together we have taken the once wish of biologists' wildest dreams, and begun to make it a reality.
 M. Valenzuela-Ortega and C. French, “Joint universal modular plasmids (JUMP): a flexible vector platform for synthetic biology,” Synthetic Biology, vol. 6, no. 1, Jan. 2021, doi: https://doi.org/10.1093/synbio/ysab003.