B-CELLS ARE HEROES OF OUR IMMUNE SYSTEM

WE TURN THEM INTO SUPERHEROES

IN THEIR BATTLE AGAINST THREATS, B-CELLS ROLL THE DICE TO GENERATE THE RIGHT ANTIBODY.

WE THINK SOME DISEASES ARE TOO DANGEROUS TO LEAVE THE DEFENCE AGAINST THEM UP TO CHANCE

WE PROPOSE A NOVEL THERAPY: B-CELLS THAT ARE ENGINEERED TO EXPRESS ANTIBODIES AGAINST A SPECIFIC TARGET...

SUCH AS CANCER ANTIGENS, WHERE OUR BEE-CELLS BOOST LOCAL IMMUNITY AND PREVENT RELAPSE FOR LIFE

CHRONIC VIRAL INFECTIONS, WHERE OUR BEE CELLS UNDERGO CLASS SWITCHING AND SOMATIC HYPERMUTATION TO COMBAT RAPIDLY MUTATING VIRUSES

ACUTE MRSA BACTERIAL INFECTIONS, WHERE OUR BEE-CELLS OFFER PROPHYLACTIC PROTECTION FOR HIGH-RISK PATIENTS

NEURODEGENERATIVE DISEASES, WHERE OUR BEE-CELLS IDENTIFY AND RESOLVE THREATS BEFORE SYMPTOMS OCCUR

WE INTRODUCE CUSTOM ANTIBODIES INTO THE ENDOGENOUS LOCUS, MAKING OUR APPROACH APPLICABLE TO ANY TARGET

COMPATIBLE WITH ADDITIONAL BINDING DOMAINS: OUR BBB-SHUTTLE, LINKED ANTIBODY CHAINS FOR SIMPLFIED ENGENEERING OR ANTIBODY DERIVATES

WITH GREAT POWER COMES GREAT RESPONSIBILITY. THAT’S WHY OUR PLATFORM COMES WITH ADDITIONAL SAFETY FEATURES

FOR THIS WE IMPLEMENT A CASCADE SAFETY MECHANISM: KILL SWITCH, DEPLETION FACTOR, MODULATION SWITCH, AND OVER-EXPRESSION MARKER

EXPLORE THIS WIKI TO LEARN HOW WE PLAN TO MAKE THESE SKETCHES REALITY.