Abstract
The cardiovascular and cerebrovascular diseases (CCVD) caused by atherosclerosis (AS) rank first among various causes of death in the world, especially in an aging society, such as China. In our project, we endeavored to develop a detector used for the early screening of AS by detecting trimethylamine N-oxide (TMAO) and microRNAs (miR-17-5p and miR-146a-5p), all of which were reported high concentration in the urine of patients. This detector uses a filter paper biosensor to detect TMAO and miRNAs based on TMAO receptor system and toehold switch, respectively, in cell free expression system. Due to the portability, it facilitates the early screening of AS at home, providing an early warning followed by early intervention to avoid of CCVD caused by AS, which is the most risk factor for the elderly people health.
This is a story of my grandpa.
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