Almost 50% of people will develop some form of cancer in their lifetime. Approximately 90% of adult human cancers are solid tumors. Solid tumors, such as those found in the breast, lung, or colon, pose a significant health challenge due to their ability to grow and spread rapidly, often requiring complex treatment strategies.

Current Approaches

Chimeric antigen T-cell (CAR-T) therapy is an emerging immunotherapy that reprograms a patient's own T-cells to target cancer cells based on their expressed antigens. CAR-T cell therapy has proved effective in blood cancers, but unsucessful in tackling solid tumors. Recently, synthetic biology approaches to create CAR-T cells secreting cytokines aim to increase T-cell activation in fighting cancer. However, these strategies neglect the potential challenge of cytokine release syndrome (CRS), a condition that can lead to deadly complications.


We developed ICARUS, Intelligent CAR Upregulation System, a platform that allows for enhanced T cell activation, mitigation of CRS and ultimately, a more cost-effective solution to treat a diverse set of solid and bloodborne tumors.


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