Colorectal cancer(CRC) is a malignant tumor, ranking as the second most common cancer in the world.
It has claimed many lives and left many families penniless.
Despite numerous treatments, the clinical needs are still far to be met,
So new solution is in an urgent need.
CRC onset is deeply intertwined with the gut microbiome. Among all intestinal bacteria, Fusobacterium nucleatum (Fn) stands out as a key culprit.
It is attached to cancer cells and colonizes in colon, which greatly influences tumor growth, metastasis and immune escape.
Although antibiotics can effectively clear Fn and help tumor regression, antibiotic resistance is inevitable.
