Cancer refers to a large group of diseases in which abnormal cells divide uncontrollably, invade nearby tissues or spread to other organs and damage body tissues. Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. Additionally, aside from the psychological and financial burden experienced by patients and their families, cancer treatment also poses a significant burden on society.

Despite recent advancements in cancer treatment, many types of cancer still lack effective therapeutic approaches. Furthermore, even when a treatment exists, issues such as relapse and drug resistance persist. Therefore, further research and innovation are needed to develop more effective cancer treatments and provide better health protection for the world.

The Problems
  • Surgery is only effective for benign and early-stage malignant lesions.
  • Radiation therapy often faces challenges such as low tumor responsiveness and tumor recurrence. Moreover, there is a lifetime dose limit.
  • Chemotherapy can cause various side effects and lead to drug resistance.
  • Targeted Therapy is limited to specific types of cancer with identifiable targets, and drug resistance can arise in some cases.
  • Immunotherapy has some potential problems, such as adverse reactions, overactive immune system, long time to work, and not working for everyone.

The existence of viruses seems to only bring disaster and pain to society, causing people to avoid them at all costs. However, the vast majority of viruses are not pathogenic to humans, and many play an indispensable role in supporting the ecosystem.

If we effectively utilize viruses, could they benefit humanity?

If viruses can kill normal cells,
can they also be used to kill tumor cells?

o n c o l y t i c    v i r u s

Its principle is to genetically modify some viruses in nature into oncolytic viruses, so that they can selectively infect tumor cells, can replicate in large numbers in the tumor and eventually kill the tumor.

Our Project

Oncolytic virus is an extremely common virus. But the natural Oncolytic virus is too poor at targeting tumor tissue. We plan to genetically modify some of the surface proteins of Oncolytic virus and their content so that they can accurately target tumors.
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