SAeking

Staphylococcus aureus (S. aureus) is a common pathogen that often causes skin infections and food poisoning. Recent research also shows that the human digestive tract is its long-ignored reservoir. Our project develops an efficient and cost-effective detection and elimination kit for S. aureus Detection is accomplished by heterogeneous application of the S. aureus quorum sensing (QS) pathway.

Autoinducer peptides (AIPs) in the pathway act as intercellular communication molecules and activate the P2 promoter, further inducing E. coli lysis through endolysin SPN1S_Lys RZ, releasing S. aureus-specific Endolysin ClyC, LysDZ25, LysGH15, and antimicrobial peptide (AMP) LL-37 to achieve elimination.