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B a c 2 G L O W 🧪

Shining a light on the water contamination crisis.
Bac2Glow logo

2 bn 🚱

People, worldwide, consume contaminated water

485,000 👩‍⚕️

People die from diarrhea-related deaths every year.

80% 🚨

Of wastewater flows back to the envrioment without treatment.

Source

THE PROBLEM

There are many different scenarios in which pathogens are present and shouldnt be: On hostpital wards, within industial production lines, in our food, or in drinking water. Yet, in many of these scenarios we do not test for bacteria. In paticular, in many developing regions there are issues with testing water containmination. In these regions containmination can either occur at the source or in the personal storage containers. This means we need a test that can target both of these situations.

There simply are no current tests that are cheap, easy to transport, and accurate. We believe that current developments in protein engineering and protein design make it possible to develop pathogen tests that target native proteins. The most common culprite for water containmination in these regions in E. coli. E. coli is a well documented pathogen that we can target with the newly developed biosensor technology. Our mission is to prove that it is possible to make these biosensors within a summer and show that we can progress to a time where we have tests for most common pathogens.

OUR PROJECT FOCUS

Bac2Glow focusses on improving the ability to detect common pathogens, specificially in low resource locations. Our technology is built on top of the Baker Lab's modular biosensor work. The Baker Lab has created a modular biosensor that consists of a cage and a key. When the cage binds to a specificed epitope, it changes conformation, allowing the key to insert. When the cage and key combine there is a reconsitution of luciferase, which emits a signal.
It is fast. One can obtain results in a matter of minutes.
It is easy to transport. The biosensor is made from stable proteins.
It is easy to interpret. A positive signal is simply an exponential change in luminescence.

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